Hardie, D. L., Baldwin, M. J., Naylor, A., Haworth, O. J., Hou, T. Z., Lax, S., Curnow, S. J., Willcox, N., MacFadyen, J., Isacke, C. M., Buckley, C. D. (2011) The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+human T cells and regulates proliferation. Immunology, 133 (3). pp. 288-295. ISSN 0019-2805

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Abstract

P>CD248 (endosialin) is a transmembrane glycoprotein that is dynamically expressed on pericytes and fibroblasts during tissue development, tumour neovascularization and inflammation. Its role in tissue remodelling is associated with increased stromal cell proliferation and migration. We show that CD248 is also uniquely expressed by human, but not mouse (C57BL/6), CD8+ naive T cells. CD248 is found only on CD8+ CCR7+ CD11alow naive T cells and on CD8 single-positive T cells in the thymus. Transfection of the CD248 negative T-cell line MOLT-4 with CD248 cDNA surprisingly reduced cell proliferation. Knock-down of CD248 on naive CD8 T cells increased cell proliferation. These data demonstrate opposing functions for CD248 on haematopoietic (CD8+) versus stromal cells and suggests that CD248 helps to maintain naive CD8+ human T cells in a quiescent state.

Item Type:	Article
Authors (ICR Faculty only):	Isacke, Clare
All Authors:	Hardie, D. L., Baldwin, M. J., Naylor, A., Haworth, O. J., Hou, T. Z., Lax, S., Curnow, S. J., Willcox, N., MacFadyen, J., Isacke, C. M., Buckley, C. D.
Additional Information:	ISI Document Delivery No.: 772GW Times Cited: 0 Cited Reference Count: 33 Hardie, Debbie L. Baldwin, Mathew J. Naylor, Amy Haworth, Oliver J. Hou, Tie Zheng Lax, Sian Curnow, S. John Willcox, Nick MacFadyen, John Isacke, Clare M. Buckley, Christopher D. ARC-UK ; MRC ; Breakthrough Breast Cancer The authors would like to acknowledge support from ARC-UK, MRC and Breakthrough Breast Cancer. We thank Ewan Ross, Dagmar Scheel-Toellner, Roger Bird and Steve Kissane for advice and technical assistance. Wiley-blackwell Malden
Uncontrolled Keywords:	angiogenesis CD248 endosialin CD8 naive T cells tumour therapy tumor endothelium therapeutic target marker pericytes tem1 tumor-endothelial-marker-1 fibroblasts lymphocytes antibodies migration
Research teams:	ICR divisions > Breast Cancer Research > Molecular Cell Biology
Depositing User:	Users 11 not found.
Date Deposited:	21 Jun 2011 10:27
Last Modified:	10 Aug 2011 14:00
URI:	http://publications.icr.ac.uk/id/eprint/10794

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