Suzuki, R. N., Entwistle, A., Atherton, A. J., Clarke, C., Lakhani, S. R., O'Hare, M. J. (2002) The expression patterns of integrin subunits on human breast tissues obtained during pregnancy. CELL BIOLOGY INTERNATIONAL, 26 (7). pp. 593-598. ISSN 1065-6995

Full text not available from this repository.

Abstract

The expression patterns of integrin subunits on human breast tissues obtained during pregnancy Integrins have been shown to exert regulatory influences on mammary differentiation and morphogenesis in rodent experimental systems. We have, therefore, examined the expression patterns of integrin subunits on human breast tissues obtained at the 12th, 15th and 18th weeks of pregnancy. Myoepithelial cells were positive for all the integrin subunits examined. alpha2, alpha6 and beta4 showed increased and more defined labelling during pregnancy, indicating that myoepithelial cells and extracellular matrix strengthen their support for the expanding alveoli during pregnancy. Sub-populations of stromal cells were positive for alpha1, alpha3, alpha6, beta1 and beta4. On luminal epithelial cells, alpha1, alpha2, alpha3, alpha6 and beta1 were detectable. alpha2 showed a focal decrease, but the expression patterns of other integrins in luminal cells did not change during pregnancy. Therefore, the expression patterns of most integrins existing prior to pregnancy seem sufficient in this cell type to support the morphological and functional development during early pregnancy.

Item Type:	Article
All Authors:	Suzuki, R. N., Entwistle, A., Atherton, A. J., Clarke, C., Lakhani, S. R., O'Hare, M. J.
Research teams:	Closed research groups > Other closed groups
Depositing User:	EPrints Services
Date Deposited:	10 Aug 2007 20:40
Last Modified:	07 Apr 2015 14:41
URI:	http://publications.icr.ac.uk/id/eprint/1083

Actions (login required)

View Item