Endesfelder, D., McGranahan, N., Birkbak, N. J., Szallasi, Z., Kschischo, M., Graham, T. A., Swanton, C. (2011) A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables. ONCOTARGET, 2 (7). pp. 529-537. ISSN 1949-2553

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Abstract

Breast cancer in younger patients often presents with adverse histopathological features, including increased frequency of estrogen receptor negative and lymph node positive disease status. Chromosomal instability (CIN) is increasingly recognised as an important prognostic variable in solid tumours. In a breast cancer meta-analysis of 2423 patients we examine the relationship between clinicopathological parameters and two distinct chromosomal instability gene expression signatures in order to address whether younger age at diagnosis is associated with increased tumour genome instability. We find that CIN, assessed by the two independently derived CIN expression signatures, is significantly associated with increased tumour size, ER negative or HER2 positive disease, higher tumour grade and younger age at diagnosis in ER negative breast cancer. These data support the hypothesis that chromosomal instability may be a defining feature of breast cancer biology and clinical outcome.

Item Type:	Article
All Authors:	Endesfelder, D., McGranahan, N., Birkbak, N. J., Szallasi, Z., Kschischo, M., Graham, T. A., Swanton, C.
Additional Information:	ISI Document Delivery No.: 802KU Times Cited: 0 Cited Reference Count: 36 Endesfelder, David McGranahan, Nicholas Birkbak, Nicolai J. Szallasi, Zoltan Kschischo, Maik Graham, Trevor A. Swanton, Charles CR-UK; MRC; Inflammatory Breast Cancer UK; NIH[NCI SPORE P50 CA 89393, R21LM008823-01A1]; Breast Cancer Research Foundation CS is a Medical Research Council senior clinical research fellow. This work was funded by CR-UK, MRC, Inflammatory Breast Cancer UK, NIH (grants NCI SPORE P50 CA 89393, R21LM008823-01A1) and by the Breast Cancer Research Foundation. Impact journals llc Albany
Uncontrolled Keywords:	breast cancer age chromosomal instability histopathological parameters signature survival chemotherapy resistance prognosis profiles patterns trends tumors
Research teams:	Clinical Units > Breast Unit
Depositing User:	Alexander Smithson
Date Deposited:	31 Aug 2011 12:16
Last Modified:	31 Aug 2011 12:16
URI:	http://publications.icr.ac.uk/id/eprint/10966

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