Nielsen, T. B., Hansen, V. N., Westberg, J., Hansen, O., Brink, C. (2012) A dual centre study of setup accuracy for thoracic patients based on Cone-Beam CT data. RADIOTHERAPY AND ONCOLOGY, 102 (2). pp. 281-286. ISSN 0167-8140

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Abstract

Background and purpose: To compare setup uncertainties at two different institutions by using identical imaging and analysis techniques for thoracic patients with different fixation equipments. Methods and materials: Patient registration results from Cone-Beam CT (CBCT) scans of 174 patients were evaluated (1068 CBCT scans). Patients were fixated using a standard or custom made fixation at Royal Marsden Hospital and Odense University Hospital, respectively. Five imaging protocols were retrospectively simulated to compare the fixation equipments. Systematic and random setup uncertainties were calculated to estimate sufficient treatment margins. Results: The setup uncertainties are of similar sizes at the two institutions and there is no observable drift in the precision of the fixation equipments during the treatment course. When a correcting imaging protocol is performed there is a significant increase of the systematic setup uncertainties in between imaging fractions. A margin reduction of >= 0.2 cm can be achieved for patients with peak-to-peak respiration amplitudes of >= 1.2 cm when changing from 4D-CT to Active Breathing Coordinator (TM) (ABC). Conclusions: The setup uncertainties at the two institutions are the same despite different fixation equipments. Hence margins cannot be reduced by changing fixating equipment. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 102 (2012) 281-286

Item Type:	Article
All Authors:	Nielsen, T. B., Hansen, V. N., Westberg, J., Hansen, O., Brink, C.
Additional Information:	ISI Document Delivery No.: 900YA Times Cited: 0 Cited Reference Count: 25 Nielsen, Tine B. Hansen, Vibeke N. Westberg, Jonas Hansen, Olfred Brink, Carsten Elekta; Region of Southern Denmark; CIRRO - The Lundbeck Foundation Center for Interventional Research in Radiation Oncology; The Danish Council for Strategic Research Financial grants from Elekta for travels between the institutions are acknowledged. This work is supported by the Region of Southern Denmark and CIRRO - The Lundbeck Foundation Center for Interventional Research in Radiation Oncology and The Danish Council for Strategic Research. Elsevier ireland ltd Clare
Uncontrolled Keywords:	Fixation equipment Geometric uncertainties Cone-Beam CT Patient position verification computed-tomography lung-cancer up accuracy control abc radiotherapy tumor margins motion reduction errors
Research teams:	Clinical Units > Radiotherapy
Depositing User:	Barry Jenkins
Date Deposited:	02 Apr 2012 15:05
Last Modified:	02 Apr 2012 15:05
URI:	http://publications.icr.ac.uk/id/eprint/11492

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