Kohut, K., D'Mello, L., Bancroft, E. K., Thomas, S., Young, M. A., Myhill, K., Shanley, S., Briggs, B. H. J., Newman, M., Saraf, I. M., Cox, P., Scambler, S., Wagman, L., Wyndham, M. T., Eeles, R. A., Ferris, M. (2012) Implications for cancer genetics practice of pro-actively assessing family history in a General Practice cohort in North West London. FAMILIAL CANCER, 11 (1). pp. 107-113. ISSN 1389-9600

Full text not available from this repository.

Abstract

At present cancer genetics referrals are reactive to individuals asking for a referral and providing a family history thereafter. A previous pilot study in a single General Practice (GP) catchment area in North London showed a 1.5-fold increase in breast cancer risk in the Ashkenazi Jewish population compared with the non-Ashkenazi mixed population. The breast cancer incidence was equal in the Ashkenazim in both pre- and postmenopausal groups. We wanted to investigate the effect of proactively seeking family history data from the entire female population of the practice to determine the effect on cancer genetics referral. Objectives To determine the need for cancer genetics intervention for women in a single GP catchment area. (1) to determine the incidence and strength of family history of cancer in women aged over 18 in the practice, (2) to offer cancer genetics advice and determine the uptake of counselling in those with a positive family history, (3) to identify potential BRCA1/BRCA2 gene mutation carriers who can be offered clinical follow up with appropriate translational research studies. Design Population-based cohort study of one General Practice female population. Participants Three hundred and eighty-three women over the age of 18 from one General Practice who responded to a questionnaire about family history of cancer. The whole female adult GP population was the target and the total number sampled was 3,820. Results 10% of patients completed the questionnaire (n = 383). A family history of cancer was present in 338 cases, 95 went on to have genetic counselling or had previously had counselling and 47 were genetically tested. We identified three carriers of an Ashkenazi Jewish founder mutation in BRCA1. Conclusions Response rate to a family history questionnaire such as that used in genetics centres was low (10%) and other approaches will be needed to proactively assess family history. Although the Ashkenazim are present in 39% of the GP catchment area, 62% of those who returned a family history questionnaire were from this ethnic group and of those returned, 44% warranted referral to a cancer genetics unit. In the non Ashkenazim, the questionnaire return rate was 38% and 18% of those warranted referral to cancer genetics.

Item Type:	Article
Authors (ICR Faculty only):	Eeles, Rosalind
All Authors:	Kohut, K., D'Mello, L., Bancroft, E. K., Thomas, S., Young, M. A., Myhill, K., Shanley, S., Briggs, B. H. J., Newman, M., Saraf, I. M., Cox, P., Scambler, S., Wagman, L., Wyndham, M. T., Eeles, R. A., Ferris, M.
Additional Information:	ISI Document Delivery No.: 908RR Times Cited: 0 Cited Reference Count: 12 Kohut, Kelly D'Mello, Lucia Bancroft, Elizabeth K. Thomas, Sarah Young, Mary-Anne Myhill, Kathryn Shanley, Susan Briggs, Brian H. J. Newman, Michelle Saraf, Ifthikhar M. Cox, Penny Scambler, Sarah Wagman, Lyndon Wyndham, Michael T. Eeles, Rosalind A. Ferris, Michelle NocLOR; David and Frederick Barclay Foundation; Billingsgate Christian Mission Charitable Trust from The Fishmongers' Company; Professor Eeles' research fund; NIHR; Royal Marsden NHS Foundation Trust This work is dedicated to the memory of Denise Pannick and Nicola Goldfarb. Funding was provided by NocLOR, The David and Frederick Barclay Foundation, Billingsgate Christian Mission Charitable Trust from The Fishmongers' Company and Professor Eeles' research fund. We acknowledge support from the NIHR to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. Springer Dordrecht
Uncontrolled Keywords:	Ashkenazi Jewish Gene testing General practice Cancer risk Ashkenazi BRCA1 BRCA2 brca2 mutation carriers ashkenazi jews breast risks women
Research teams:	ICR divisions > Genetics and Epidemiology > Oncogenetics ICR divisions > Radiotherapy and Imaging > Oncogenetics
Depositing User:	Alexander Smithson
Date Deposited:	01 May 2012 16:30
Last Modified:	01 May 2012 16:30
URI:	http://publications.icr.ac.uk/id/eprint/11508

Actions (login required)

View Item