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Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis

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Wilkinson, M. J., Fitzgerald, J. E. F., Thomas, J. M., Hayes, A. J., Strauss, D. C. (2012) Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis. BRITISH JOURNAL OF SURGERY, 99 (5). pp. 706-713. ISSN 0007-1323

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Abstract

Background: Intra-abdominal fibromatosis (IAF) in the context of familial adenomatosis polyposis (FAP) is associated with significant morbidity and high recurrence rates after surgical resection. Non-surgical treatments are therefore advocated. This study explored outcomes in patients with IAF not associated with FAP who underwent surgical resection. Methods: Data were analysed from a prospectively collected database at a sarcoma tertiary referral centre. Results: From 2001 to 2011, 15 patients without FAP underwent primary curative surgical resection of IAF. Their median (range) age was 42 (19-64) years. Median tumour size was 18 (8.5-25) cm and weight 1306 (236-2228) g. Complete macroscopic clearance was obtained in all patients. There were no deaths in hospital or within 30 days and only one patient developed a major complication. Median follow-up was 40 (6-119) months. During follow-up two patients developed a recurrence after a disease-free interval of 12 and 16 months. Conclusion: In contrast to FAP-associated IAF, non-FAP-associated IAF has a very low recurrence rate after surgical resection. Surgical resection is therefore advocated as first-line treatment in patients with non-FAP-associated IAF when resection can be performed with low morbidity.

Item Type: Article
All Authors: Wilkinson, M. J., Fitzgerald, J. E. F., Thomas, J. M., Hayes, A. J., Strauss, D. C.
Additional Information: ISI Document Delivery No.: 930PD Times Cited: 0 Cited Reference Count: 37 Wilkinson, M. J. Fitzgerald, J. E. F. Thomas, J. M. Hayes, A. J. Strauss, D. C. International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland May, 2010 Bournemouth, ENGLAND Assoc Surg Great Britain & Ireland Wiley-blackwell Malden
Uncontrolled Keywords: soft-tissue tumors core needle-biopsy desmoid tumors risk-factors management diagnosis surgery mutations disease cohort
Research teams: Clinical Units > Sarcoma Unit
Clinical Units > Skin Unit
Depositing User: Barry Jenkins
Date Deposited: 22 May 2012 14:28
Last Modified: 22 May 2012 14:28
URI: http://publications.icr.ac.uk/id/eprint/11646

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