Berry, J. M., Howard, P. W., Kelland, L. R., Thurston, D. E. (2002) Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 12 (10). pp. 1413-1416. ISSN 0960-894X

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Abstract

Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug. The first example of an N10-protected. (e.g., Psec, 15) pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogue that retains significant cytotoxicity in a number of tumour cell lines is reported. This prototype could lead to a new generation of clinically useful N10-protceted PBD prodrugs.

Item Type:	Article
Authors (ICR Faculty only):	Kelland, Lloyd
All Authors:	Berry, J. M., Howard, P. W., Kelland, L. R., Thurston, D. E.
Uncontrolled Keywords:	DESIGN; ENEDIYNES; POTENT
Research teams:	Closed research groups > Other closed groups
Depositing User:	EPrints Services
Date Deposited:	10 Aug 2007 20:41
Last Modified:	19 Aug 2011 15:23
URI:	http://publications.icr.ac.uk/id/eprint/1175

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