Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug
Berry, J. M., Howard, P. W., Kelland, L. R., Thurston, D. E.
(2002)
Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 12 (10).
pp. 1413-1416.
ISSN 0960-894X
Full text not available from this repository.
Abstract
Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug. The first example of an N10-protected. (e.g., Psec, 15) pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogue that retains significant cytotoxicity in a number of tumour cell lines is reported. This prototype could lead to a new generation of clinically useful N10-protceted PBD prodrugs.
Item Type: | Article |
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Authors (ICR Faculty only): | Kelland, Lloyd |
All Authors: | Berry, J. M., Howard, P. W., Kelland, L. R., Thurston, D. E. |
Uncontrolled Keywords: | DESIGN; ENEDIYNES; POTENT |
Research teams: | Closed research groups > Other closed groups |
Depositing User: | EPrints Services |
Date Deposited: | 10 Aug 2007 20:41 |
Last Modified: | 19 Aug 2011 15:23 |
URI: | http://publications.icr.ac.uk/id/eprint/1175 |
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