Does tumour biology determine surgical success in the treatment of epithelial ovarian cancer? A systematic literature review
Borley, J., Wilhelm-Benartzi, C., Brown, R., Ghaem-Maghami, S.
Does tumour biology determine surgical success in the treatment of epithelial ovarian cancer? A systematic literature review.
BRITISH JOURNAL OF CANCER, 107 (7).
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BACKGROUND: Ovarian cancer is the most lethal gynaecological cancer. Progression- free and overall survival is significantly related to surgical success and residual disease volume. It is unclear whether this survival advantage is due to an intrinsic biological element of the tumour cells which enables successful surgery and improved prognosis, or alternatively the number of tumour sustaining cells remaining irrespective of differences in biology. METHODS: A systematic review of the literature was performed identifying studies that have investigated the association between biomarkers and surgical outcomes. We attempted validation of these results using The Cancer Genome Atlas ovarian cancer data sets. RESULTS: Thirty studies were identified of which sixteen determined protein expression, eight gene expression and one DNA methylation in association with surgical debulking. Individualised linear models adjusting for batch, stage and age identified only expression of the genes MTDH and insulin-like growth factor-1 receptor (IGFIR) to be significantly associated with debulking surgery (P < 0.05, false discovery rate (FDR) < 5%), although in the case of IGFIR this was in the opposite direction to previous findings. CONCLUSION: The majority of studies are limited by design, include heterogeneous samples and lack adjustment for major confounding factors. High quality detailed clinical annotations should be routinely collected in future to more accurately evaluate biomarkers of surgical outcome. British Journal of Cancer (2012) 107, 1069-1074. doi:10.1038/bjc.2012.376 www.bjcancer.com Published online 30 August 2012 (c) 2012 Cancer Research UK
|Item Type:||Review Article|
|Authors (ICR Faculty only):||Brown, Robert|
|All Authors:||Borley, J., Wilhelm-Benartzi, C., Brown, R., Ghaem-Maghami, S.|
|Additional Information:||ISI Document Delivery No.: 016SW Times Cited: 0 Cited Reference Count: 59 Borley, J. Wilhelm-Benartzi, C. Brown, R. Ghaem-Maghami, S. Nature publishing group London|
|Uncontrolled Keywords:||ovarian cancer debulking surgery molecular biomarkers primary cytoreductive surgery prognostic-factors neoadjuvant chemotherapy progression-free survival carcinoma expression p53 receptor gene|
|Research teams:||ICR divisions > Molecular Pathology > Medicine (Brown Epigenetic Therapy)|
|Depositing User:||Peter Knox|
|Date Deposited:||13 Nov 2012 12:59|
|Last Modified:||13 Nov 2012 12:59|
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