Institute of Cancer Research Repository - Genomic analyses to select patients for adjuvant chemotherapy: trials and tribulations

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Genomic analyses to select patients for adjuvant chemotherapy: trials and tribulations

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Weigelt, B., Reis-Filho, J. S., Swanton, C. (2012) Genomic analyses to select patients for adjuvant chemotherapy: trials and tribulations. ANNALS OF ONCOLOGY, 23. pp. 211-218. ISSN 0923-7534

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A copy of the full text may be available at: http://annonc.oxfordjournals.org/content/23/1/211....

Abstract

Despite improvements in adjuvant chemotherapy regimens in breast cancer; personalised use of specific cytotoxic regimens remains a clinical challenge. Defining the correct therapeutic strategy for individual patients with breast cancer based on the genomic and transcriptomic characteristics of the tumour and the patient remains an area of unmet clinical need. Despite the promise of microarray-based predictors of response to chemotherapy, clinical decisions are still guided by a limited constellation of biomarkers. In this review we will address current genomic and transcriptomic approaches to the stratification of adjuvant therapies in breast cancer, the reasons for the limited success in the incorporation of novel multi-gene predictors of response to chemotherapy in clinical practice and focus on new approaches that aim to understand the clonal evolution of the disease. The polygenic nature of drug resistance, and inter- and intra-tumour heterogeneity are considered as important research areas, given that they may constitute important challenges for the development of chemotherapy-specific response predictors.

Item Type:	Article
Authors (ICR Faculty only):	Reis-Filho, Jorge
All Authors:	Weigelt, B., Reis-Filho, J. S., Swanton, C.
Additional Information:	ISI Document Delivery No.: 014YA Times Cited: 0 Cited Reference Count: 103 Weigelt, B. Reis-Filho, J. S. Swanton, C. Oxford univ press Oxford 10
Uncontrolled Keywords:	breast cancer gene expression profiling intra-tumour heterogeneity predictive gene signatures gene-expression patterns negative breast-cancer long-term survival preoperative chemotherapy chromosomal instability retrospective analysis molecular subtypes clonal selection multidrug-resistance distant recurrence
Research teams:	Closed research groups > Molecular Pathology
Depositing User:	Users 11 not found.
Date Deposited:	13 Nov 2012 12:11
Last Modified:	16 Apr 2014 15:03
URI:	http://publications.icr.ac.uk/id/eprint/12033

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