Ally, M. S., Hunasehally, R. Y. P., Rodriguez-Justo, M., Martin, B., Verdolini, R., Attard, N., Child, F., Attygalle, A., Whittaker, S., Morris, S., Robson, A. (2013) Evaluation of follicular T-helper cells in primary cutaneous CD4+small/medium pleomorphic T-cell lymphoma and dermatitis. JOURNAL OF CUTANEOUS PATHOLOGY, 40 (12). pp. 1006-1013. ISSN 0303-6987

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Abstract

BackgroundCD4+ small/medium-sized pleomorphic T-cell lymphoma (SMPTCL) is a controversial primary cutaneous lymphoma, in which the candidate neoplastic cells express a follicular T-helper phenotype. We describe 16 cases of SMPTCL and compare expression of PD-1, CXCL-13 and ICOS in these tumors with 40 dermatitis cases. MethodsHistopathologic examination and immunocytochemistry were performed for 16 tumors and 40 assorted dermatitis cases. ResultsAll but one patient presented with solitary lesions. Each biopsy revealed a dense nodular non-epitheliotropic infiltrate of atypical T-cells. Neoplastic cells were CD3+/CD4+/CD8(-)/CD30(-). Cutaneous recurrence occurred in one patient over a median follow up of 8months (range 5-36). All tumors widely expressed PD-1 and ICOS to a lesser extent. CXCL-13 stained much fewer cells. Of the dermatitis cases, PD-1 (most numerous) and ICOS labeled lymphoid cells in all cases, albeit fewer than in the tumors, and CXCL-13 was negative in 32. A rosette pattern of PD-1 expression was identified in all the SMPTCL cases but not in dermatitis. ConclusionsThere remains uncertainty about the appropriate nosological status of SMPTCL, which some authors consider to be a pseudolymphoma. However, this study suggests a significant difference in the prevalence and pattern of follicular T-helper cell markers between this tumor and lymphoid proliferations known to be reactive.

Item Type:	Article
All Authors:	Ally, M. S., Hunasehally, R. Y. P., Rodriguez-Justo, M., Martin, B., Verdolini, R., Attard, N., Child, F., Attygalle, A., Whittaker, S., Morris, S., Robson, A.
Additional Information:	ISI Document Delivery No.: 256QY Times Cited: 0 Cited Reference Count: 28 Ally, Mina S. Hunasehally, Ranganna Y. Prasad Rodriguez-Justo, Manuel Martin, Blanca Verdolini, Roberto Attard, Natalie Child, Fiona Attygalle, Ayoma Whittaker, Sean Morris, Stephen Robson, Alistair 0 WILEY-BLACKWELL HOBOKEN J CUTAN PATHOL
Uncontrolled Keywords:	cutaneous lymphoma follicular T-helper cell PD-1 pseudolymphoma small medium pleomorphic T-cell lymphoma OF-THE-LITERATURE CLINICOPATHOLOGICAL FEATURES PROGRAMMED DEATH-1 MYCOSIS-FUNGOIDES SEZARY-SYNDROME EXPRESSION CLASSIFICATION SERIES
Research teams:	Clinical Units > Skin Unit
Depositing User:	Users 11 not found.
Date Deposited:	12 Dec 2013 10:44
Last Modified:	12 Dec 2013 10:44
URI:	http://publications.icr.ac.uk/id/eprint/12883

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