Hiley, C., de Bruin, E. C., McGranahan, N., Swanton, C. (2014) Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine. GENOME BIOLOGY, 15 (8). p. 10. ISSN 1474-760X

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Abstract

The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.

Item Type:	Review Article
All Authors:	Hiley, C., de Bruin, E. C., McGranahan, N., Swanton, C.
Additional Information:	ISI Document Delivery No.: AW9UU Times Cited: 3 Cited Reference Count: 70 Hiley, Crispin de Bruin, Elza C. McGranahan, Nicholas Swanton, Charles National Institute for Health Research Academic Clinical Fellowship; Cancer Research UK; Rosetrees Trust; EU [259303]; Prostate Cancer Foundation; European Research Council; Breast Cancer Research Foundation; National Institute for Health Research University College London Hospital Biomedical Research Centre ECdB is a Rosetrees Trust fellow, CH is funded by the National Institute for Health Research Academic Clinical Fellowship and CS is funded by Cancer Research UK, the Rosetrees Trust, EU FP7 (projects PREDICT and RESPONSIFY, ID: 259303), the Prostate Cancer Foundation, the European Research Council, the Breast Cancer Research Foundation, and is supported by the National Institute for Health Research University College London Hospital Biomedical Research Centre. 3 BIOMED CENTRAL LTD LONDON GENOME BIOL
Uncontrolled Keywords:	CELL LUNG-CANCER 21 BREAST CANCERS TUMOR HETEROGENEITY PROSTATE-CANCER GENETIC-HETEROGENEITY MOLECULAR-MECHANISMS ACQUIRED-RESISTANCE COLORECTAL-CANCER PANCREATIC-CANCER DRUG-RESISTANCE Biotechnology & Applied Microbiology Genetics & Heredity
Research teams:	ICR divisions > Radiotherapy and Imaging > Clinical Academic Radiotherapy (Huddart)
Depositing User:	Users 11 not found.
Date Deposited:	15 Jan 2015 15:53
Last Modified:	15 Jan 2015 15:53
URI:	http://publications.icr.ac.uk/id/eprint/13834

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