Hennedige, T., Koh, T. S., Hartono, S., Yan, Y. Y., Song, I. C., Zheng, L., Lee, W. S., Rumpel, H., Martarello, L., Khoo, J. B., Koh, D. M., Chuang, K. H., Thng, C. H. (2015) Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction. MAGNETIC RESONANCE IMAGING, 33 (10). pp. 1324-1328. ISSN 0730-725X

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Abstract

Purpose: To evaluate non-invasive imaging biomarkers for assessing renal fibrosis. DWI is used to assess renal function; intravoxel incoherent motion (IVIM) provides additional measures of perfusion-related diffusion (D*, blood flow; f, perfusion fraction). We aim to determine if reduced ADC seen in renal fibrosis is attributable to perfusion-related diffusion changes or to known reduction in tissue diffusivity (D). Materials and methods: Unilateral ureteral obstruction (UUO) was created in six mice to induce renal fibrosis. DWI was performed the day before and 7 days post-UUO. A range of b-values from 0 to 1200 s/mm(2) were used. IVIM parameters were obtained using region of interests drawn over the renal parenchyma. Histopathological analysis of both kidneys was performed in all mice. Results were analyzed using the paired t-test with P<0.05 considered statistically significant. Results: D and f were significantly lower in the ligated kidneys at Day 7 compared to before ligation and no significant difference was found for D*. Comparing non-ligated and ligated kidneys within the same mouse at Day 7, significantly lower D values were observed in the ligated kidneys, while no significant difference was found for f and D*, although the values of f were generally lower. Histopathological analysis confirmed development of fibrosis and reduction in glomeruli in all the ligated kidneys at Day 7. Conclusion: Our study shows that the reduction in ADC seen in renal fibrosis is attributable not only to reduced D as previously encountered but also a decrease in vascularity as assessed by f. Reduction in f is possibly related to a reduction in glomeruli. (C) 2015 Elsevier Inc. All rights reserved.

Item Type:	Article
Authors (ICR Faculty only):	Koh, Dow-Mu
All Authors:	Hennedige, T., Koh, T. S., Hartono, S., Yan, Y. Y., Song, I. C., Zheng, L., Lee, W. S., Rumpel, H., Martarello, L., Khoo, J. B., Koh, D. M., Chuang, K. H., Thng, C. H.
Additional Information:	ISI Document Delivery No.: CX8EG Times Cited: 0 Cited Reference Count: 23 Hennedige, Tiffany koh, Tong San Hartono, Septian Yan, Yet Yen Song, In Chin Zheng, Lin Lee, Wing Sum Rumpel, Helmut Martarello, Laurent Khoo, James B. Koh, Dow-Mu Chuang, Kai Hsiang Thng, Choon Hua 0 2 Elsevier science inc New york 1873-5894
Uncontrolled Keywords:	Kidney Magnetic resonance imaging Intravoxel incoherent motion Diffusion weighted imaging focal hepatic-lesions interstitial fibrosis transplanted kidneys initial-experience diffusion motion perfusion injury challenges mice Radiology, Nuclear Medicine & Medical Imaging
Research teams:	Clinical Units > Department of Diagnostic Radiology
Depositing User:	Franziska Noessig
Date Deposited:	04 Jan 2016 13:00
Last Modified:	04 Jan 2016 13:00
URI:	http://publications.icr.ac.uk/id/eprint/14647

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