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Targeting Androgen Receptor Aberrations in Castration-Resistant Prostate Cancer

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Sharp, A., Welti, J., Blagg, J., de Bono, J. S. (2016) Targeting Androgen Receptor Aberrations in Castration-Resistant Prostate Cancer. CLINICAL CANCER RESEARCH, 22 (17). pp. 4280-4282. ISSN 1078-0432

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A copy of the full text may be available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53021...

Abstract

Androgen receptor (AR) splice variants (SV) have been implicated in the development of metastatic castration-resistant prostate cancer and resistance to AR targeting therapies, including abiraterone and enzalutamide. Agents targeting AR-SV are urgently needed to test this hypothesis and further improve the outcome of patients suffering from this lethal disease. (C) 2016 AACR.

Item Type: Editorial
Authors (ICR Faculty only): De Bono, Johann and Blagg, Julian
All Authors: Sharp, A., Welti, J., Blagg, J., de Bono, J. S.
Additional Information: ISI Document Delivery No.: DV6IR Times Cited: 0 Cited Reference Count: 12 Sharp, Adam Welti, Jonathan Blagg, Julian de Bono, Johann S. 0 AMER ASSOC CANCER RESEARCH PHILADELPHIA CLIN CANCER RES
Uncontrolled Keywords: DOMAIN
Research teams: ICR divisions > Cancer Therapeutics > Medicinal Chemistry 1 (including Analytical Chemistry and In Silico Chemistry)
ICR divisions > Cancer Therapeutics > Cancer Biomarkers
ICR divisions > Clinical Studies > Cancer Biomarkers

ICR divisions > Clinical Studies > Prostate Cancer Targeted Therapy Group
Depositing User: Barry Jenkins
Date Deposited: 14 Oct 2016 15:00
Last Modified: 10 Jul 2017 15:17
URI: http://publications.icr.ac.uk/id/eprint/15357

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