Schache, A. G., Powell, N. G., Cuschieri, K. S., Robinson, M., Leary, S., Mehanna, H., Rapozo, D., Long, A., Cubie, H., Junor, E., Monaghan, H., Harrington, K. J., Nutting, C. M., Schick, U., Lau, A. S., Upile, N., Sheard, J., Brougham, K., West, C. M. L., Oguejiofor, K., Thomas, S., Ness, A. R., Pring, M., Thomas, G. J., King, E. V., McCance, D. J., James, J. A., Moran, M., Sloan, P., Shaw, R. J., Evans, M., Jones, T. M. (2016) HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology. CANCER RESEARCH, 76 (22). pp. 6598-6606. ISSN 0008-5472

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Abstract

A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) incidence has occurred throughout the developed world, where it has been attributed to an increasing impact of human papillomavirus (HPV) on disease etiology. This report presents the findings of a multicenter cross-sectional retrospective study aimed at determining the proportion of HPV-positive and HPV-negative OPSCC within the United Kingdom. Archival tumor tissue blocks from 1,602 patients previously diagnosed with OPSCC (2002-2011) were collated from 11 centers. HPV status was determined with three validated commercial tests to provide valid data for 1,474 cases in total. Corresponding national incidence data from the same decade were obtained from UK Cancer registries. The overall proportion of HPV+ OPSCC between 2002 and 2011 was 51.8% [95% confidence interval (CI), 49.3-54.4], and this remained unchanged throughout the decade [unadjusted RR = 1.00 (95% CI, 0.99-1.02)]. However, over the same period, the incidence of OPSCC in the broader UK population underwent a 2-fold increase [age-standardized rate 2002: 2.1 (95% CI, 1.9-2.2); 2011: 4.1 (95% CI, 4.0-4.3)]. Although the number of OPSCCs diagnosed within the United Kingdom from 2002 to 2011 nearly doubled, the proportion of HPV+ cases remained static at approximately 50%. Our results argue that the rapidly increasing incidence of OPSCC in the United Kingdom cannot be solely attributable to the influence of HPV. The parallel increase in HPV+ and HPV+ cases we documented warrants further investigation, so that appropriate future prevention strategies for both types of disease can be implemented. (C) 2016 AACR.

Item Type:	Article
Authors (ICR Faculty only):	Harrington, Kevin and Nutting, Chris
All Authors:	Schache, A. G., Powell, N. G., Cuschieri, K. S., Robinson, M., Leary, S., Mehanna, H., Rapozo, D., Long, A., Cubie, H., Junor, E., Monaghan, H., Harrington, K. J., Nutting, C. M., Schick, U., Lau, A. S., Upile, N., Sheard, J., Brougham, K., West, C. M. L., Oguejiofor, K., Thomas, S., Ness, A. R., Pring, M., Thomas, G. J., King, E. V., McCance, D. J., James, J. A., Moran, M., Sloan, P., Shaw, R. J., Evans, M., Jones, T. M.
Additional Information:	ISI Document Delivery No.: ED3IF Times Cited: 0 Cited Reference Count: 33 Schache, Andrew G. Powell, Ned G. Cuschieri, Kate S. Robinson, Max Leary, Sam Mehanna, Hisham Rapozo, Davy Long, Anna Cubie, Heather Junor, Elizabeth Monaghan, Hannah Harrington, Kevin J. Nutting, Christopher M. Schick, Ulrike Lau, Andy S. Upile, Navdeep Sheard, Jon Brougham, Kath West, Catharine M. L. Oguejiofor, Ken Thomas, Steve Ness, Andy R. Pring, Miranda Thomas, Gareth J. King, Emma V. McCance, Dennis J. James, Jacqueline A. Moran, Michael Sloan, Phil Shaw, Richard J. Evans, Mererid Jones, Terry M. GlaxoSmithKline Ltd.; Health and Social Research Development Division of the Public Health Agency; University of Liverpool; Aintree University Hospitals NHS Foundation Trust T.M. Jones was the recipient of a research grant provided by GlaxoSmithKline Ltd. that funded the project research costs. In addition, the Northern Ireland Biobank, which provided access to tissue samples from that region, is funded by the Health and Social Research Development Division of the Public Health Agency. The University of Liverpool and Aintree University Hospitals NHS Foundation Trust jointly provided sponsorship for the research project. 0 AMER ASSOC CANCER RESEARCH PHILADELPHIA CANCER RES
Uncontrolled Keywords:	SQUAMOUS-CELL CARCINOMA VIRAL-INDUCED CARCINOMA HUMAN-PAPILLOMAVIRUS NECK CANCERS POSITIVE TONSILLAR INTERNATIONAL HEAD POOLED ANALYSIS RISK EPIDEMIOLOGY PREVALENCE
Research teams:	ICR divisions > Cancer Biology > Targeted Therapy ICR divisions > Radiotherapy and Imaging > Targeted Therapy Clinical Units > Head & Neck Cancer Unit Clinical Units > Radiotherapy
Depositing User:	Barry Jenkins
Date Deposited:	04 Jan 2017 15:04
Last Modified:	04 Jan 2017 15:04
URI:	http://publications.icr.ac.uk/id/eprint/15549

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