Matz, M., Coleman, M. P., Sant, M., Chirlaque, M. D., Visser, O., Gore, M., Allemani, C., Grp, Concord Working (2017) The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2). GYNECOLOGIC ONCOLOGY, 144 (2). pp. 405-413. ISSN 0090-8258

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Abstract

Objective. Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods. The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. Results. During 2005-2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. Conclusions. The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal turnouts are generally associated with higher survival than type II turnouts, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions. (C) 2016 Published by Elsevier Inc.

Item Type:	Article
Authors (ICR Faculty only):	Gore, Martin
All Authors:	Matz, M., Coleman, M. P., Sant, M., Chirlaque, M. D., Visser, O., Gore, M., Allemani, C., Grp, Concord Working
Additional Information:	ISI Document Delivery No.: EJ0FY Times Cited: 0 Cited Reference Count: 31 Matz, Melissa Coleman, Michel P. Sant, Milena Dolores Chirlaque, Maria Visser, Otto Gore, Martin Allemani, Claudia Sant, Milena/0000-0002-4148-8597 Canadian Partnership Against Cancer; Cancer Focus Northern Ireland; Cancer Institute New South Wales; Cancer Research UK [C1336/A16148]; US Centers for Disease Control and Prevention (CDC) [12FED03123, ACO12036]; Swiss Re; Swiss Cancer Research Foundation; Swiss Cancer League; University of Kentucky [3049024672-12-568] We would like to thank Mr. John Butler for proposing the idea for the manuscript. This work was funded by the Canadian Partnership Against Cancer, Cancer Focus Northern Ireland, Cancer Institute New South Wales, Cancer Research UK (C1336/A16148), US Centers for Disease Control and Prevention (CDC; 12FED03123, ACO12036), Swiss Re, Swiss Cancer Research Foundation, Swiss Cancer League, and the University of Kentucky (3049024672-12-568). 0 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO GYNECOL ONCOL
Uncontrolled Keywords:	Ovarain cancer Morphology Histology Worldwide Epidemiology SEROUS CARCINOMA PATHOGENESIS ORIGIN TUMORS SUBTYPES STAGE CELL
Research teams:	Clinical Units > Gynaecology Unit Clinical Units > Renal & Melanoma Unit
Depositing User:	Barry Jenkins
Date Deposited:	06 Mar 2017 13:25
Last Modified:	07 Mar 2017 10:54
URI:	http://publications.icr.ac.uk/id/eprint/15711

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