Qiu, S., Pellino, G., Fiorentino, F., Rasheed, S., Darzi, A., Tekkis, P., Kontovounisios, C. (2017) A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer. Gastroenterology Research and Practice. ISSN 1687-6121

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Abstract

Neurotensin (NTS) is a physiologically occurring hormone which affects the function of the gastrointestinal (GI) tract. In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in the carcinogenesis of several cancers. In colorectal cancer (CRC), a significant body of evidence, from in vitro and in vivo studies, is available which elucidates the molecular biology of NTS/NTSR signalling and the resultant growth of CRC cells. There is growing clinical data from human studies which corroborate the role NTS/NTSR plays in the development of human CRC. Furthermore, blockade and modulation of the NTS/NTSR signalling pathways appears to reduce CRC growth in cell cultures and animal studies. Lastly, NTS/NTSR also shows potential of being utilised as a diagnostic biomarker for cancers as well as targets for functional imaging. We summarise the existing evidence and understanding of the role of NTS and its receptors in CRC.

Item Type:	Article
All Authors:	Qiu, S., Pellino, G., Fiorentino, F., Rasheed, S., Darzi, A., Tekkis, P., Kontovounisios, C.
Additional Information:	ISI Document Delivery No.: EN8YY Times Cited: 0 Cited Reference Count: 66 Qiu, Shengyang Pellino, Gianluca Fiorentino, Francesca Rasheed, Shahnawaz Darzi, Ara Tekkis, Paris Kontovounisios, Christos 0 HINDAWI LTD LONDON GASTROENT RES PRACT
Uncontrolled Keywords:	COLONIC EPITHELIAL-CELLS PROTEIN-KINASE-C OVER-EXPRESSION CARCINOMA CELLS BREAST-CANCER LUNG-CANCER HT29 CELLS NUDE-MICE ACTIVATION GROWTH
Research teams:	Clinical Units > Academic Surgery
Depositing User:	Barry Jenkins
Date Deposited:	25 Apr 2017 13:17
Last Modified:	25 Apr 2017 13:17
URI:	http://publications.icr.ac.uk/id/eprint/15781

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