Polychronidou, G., Karavasilis, V., Pollack, S. M., Huang, P. H., Lee, A., Jones, R. L. (2017) Novel therapeutic approaches in chondrosarcoma. FUTURE ONCOLOGY, 13 (7). pp. 637-648. ISSN 1479-6694

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Abstract

Chondrosarcoma is a malignant tumor of bones, characterized by the production of cartilage matrix. Due to lack of effective treatment for advanced disease, the clinical management of chondrosarcomas is exceptionally challenging. Current research focuses on elucidating the molecular events underlying the pathogenesis of this rare bone malignancy, with the goal of developing new molecularly targeted therapies. Signaling pathways suggested to have a role in chondrosarcoma include Hedgehog, Src, PI3k-Akt-mTOR and angiogenesis. Mutations in IDH1/2, present in more than 50% of primary conventional chondrosarcomas, make the development of IDH inhibitors a promising treatment option. The present review discusses the preclinical and early clinical data on novel targeted therapeutic approaches in chondrosarcoma.

Item Type:	Review Article
Authors (ICR Faculty only):	Huang, Paul and Jones, Robin
All Authors:	Polychronidou, G., Karavasilis, V., Pollack, S. M., Huang, P. H., Lee, A., Jones, R. L.
Additional Information:	ISI Document Delivery No.: EL1YC Times Cited: 0 Cited Reference Count: 99 Polychronidou, Genovefa Karavasilis, Vasilios Pollack, Seth M. Huang, Paul H. Lee, Alex Jones, Robin L. 0 FUTURE MEDICINE LTD LONDON FUTURE ONCOL
Uncontrolled Keywords:	chondrosarcoma HDACIs Hedgehog pathway IDH1/2 novel agents Src pathway treatment SOFT-TISSUE SARCOMA HISTONE DEACETYLASE INHIBITORS T-CELL LYMPHOMA VEGF EXPRESSION DEPENDENT ANGIOGENESIS DASATINIB SENSITIZES CARTILAGINOUS TUMORS ANTIBODY CIXUTUMUMAB MONOCLONAL-ANTIBODY SIGNALING PATHWAY
Research teams:	ICR divisions > Cancer Biology > Protein Networks Clinical Units > Drug Development Unit ICR divisions > Clinical Studies > Sarcoma Clinical Trials in children and young people ICR divisions > Molecular Pathology > Sarcoma Clinical Trials in children and young people ICR divisions > Clinical Studies > Sarcoma Clinical Trials (R Jones)
Depositing User:	Barry Jenkins
Date Deposited:	10 Apr 2017 14:35
Last Modified:	10 Apr 2017 14:35
URI:	http://publications.icr.ac.uk/id/eprint/15825

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