Kayhanian, H., Smyth, E. C., Braconi, C. (2017) Emerging molecular targets and therapy for cholangiocarcinoma. World Journal of Gastrointestinal Oncology, 9 (7). pp. 268-280. ISSN 1948-5204

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Abstract

Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agents and immunotherapy in this disease. Challenges in CCA diagnosis, treatment and trial design are discussed and we reflect on future directions which may lead to improved outcomes for CCA patients.

Item Type:	Article
All Authors:	Kayhanian, H., Smyth, E. C., Braconi, C.
Additional Information:	ISI Document Delivery No.: FA9WU Times Cited: 0 Cited Reference Count: 104 Kayhanian, Hamzeh Smyth, Elizabeth C. Braconi, Chiara 0 BAISHIDENG PUBLISHING GROUP INC PLEASANTON WORLD J GASTRO ONCOL
Uncontrolled Keywords:	Cholangiocarcinoma biliary tract cancer targeted therapy immunotherapy mutation molecular microenvironment stroma MiRNA BILIARY-TRACT CANCER GROWTH-FACTOR-RECEPTOR FLUKE-ASSOCIATED CHOLANGIOCARCINOMA MALIGNANT HUMAN CHOLANGIOCYTES ISOCITRATE DEHYDROGENASE 1 RANDOMIZED PHASE-2 TRIAL INTRAHEPATIC CHOLANGIOCARCINOMA GALLBLADDER CARCINOMA ACTIVATED MACROPHAGES ADJUVANT CHEMOTHERAPY
Research teams:	Clinical Units > Gastrointestinal Unit
Depositing User:	Barry Jenkins
Date Deposited:	07 Aug 2017 09:40
Last Modified:	07 Aug 2017 09:40
URI:	http://publications.icr.ac.uk/id/eprint/16146

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