Del Chiaro, M., Besselink, M. G., Scholten, L., Bruno, M. J., Cahen, D. L., Gress, T. M., van Hooft, J. E., Lerch, M. M., Mayerle, J., Hackert, T., Satoi, S., Zerbi, A., Cunningham, D., De Angelis, C., Giovannini, M., de-Madaria, E., Hegyi, P., Rosendahl, J., Friess, H., Manfredi, R., Levy, P., Real, F. X., Sauvanet, A., Abu Hilal, M., Marchegiani, G., Esposito, I., Ghaneh, P., Engelbrecht, M. R. W., Fockens, P., van Huijgevoort, N. C. M., Wolfgang, C., Bassi, C., Gubergrits, N. B., Verbeke, C., Kloppel, G., Scarpa, A., Zamboni, G., Lennon, A. M., Sund, M., Kartalis, N., Grenacher, L., Falconi, M., Arnelo, U., Kopchak, K. V., Oppong, K., McKay, C., Hauge, T., Conlon, K., Adham, M., Ceyhan, G. O., Salvia, R., Dervenis, C., Allen, P., Paye, F., Bartsch, D. K., Lohr, M., Mutignani, M., Laukkarinen, J., Schulick, R., Valente, R., Seufferlein, T., Capurso, G., Siriwardena, A., Neoptolemos, J. P., Pukitis, A., Segersvard, R., Aghdassi, A., Andrianello, S., Bossuyt, P., Bulow, R., Cardenas-Jaen, K., Cortegoso, P., Fontana, M., Haeberle, L., Heckler, M., Litvin, A., Mann, K., Michalski, C., Michl, P., Nappo, G., Perri, G., Persson, S., Scheufele, F., Sclafani, F., Schmidt, M., Venezia, L., Volker, F., Vullierm, M. P., Wusten, L., European Study Grp Cystic, Tum (2018) European evidence-based guidelines on pancreatic cystic neoplasms. GUT, 67 (5). pp. 789-804. ISSN 0017-5749

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Abstract

Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring < 40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter >= 40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule > 5 mm, and MPD diameter > 10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.

Item Type:	Article
Authors (ICR Faculty only):	Cunningham, David
All Authors:	Del Chiaro, M., Besselink, M. G., Scholten, L., Bruno, M. J., Cahen, D. L., Gress, T. M., van Hooft, J. E., Lerch, M. M., Mayerle, J., Hackert, T., Satoi, S., Zerbi, A., Cunningham, D., De Angelis, C., Giovannini, M., de-Madaria, E., Hegyi, P., Rosendahl, J., Friess, H., Manfredi, R., Levy, P., Real, F. X., Sauvanet, A., Abu Hilal, M., Marchegiani, G., Esposito, I., Ghaneh, P., Engelbrecht, M. R. W., Fockens, P., van Huijgevoort, N. C. M., Wolfgang, C., Bassi, C., Gubergrits, N. B., Verbeke, C., Kloppel, G., Scarpa, A., Zamboni, G., Lennon, A. M., Sund, M., Kartalis, N., Grenacher, L., Falconi, M., Arnelo, U., Kopchak, K. V., Oppong, K., McKay, C., Hauge, T., Conlon, K., Adham, M., Ceyhan, G. O., Salvia, R., Dervenis, C., Allen, P., Paye, F., Bartsch, D. K., Lohr, M., Mutignani, M., Laukkarinen, J., Schulick, R., Valente, R., Seufferlein, T., Capurso, G., Siriwardena, A., Neoptolemos, J. P., Pukitis, A., Segersvard, R., Aghdassi, A., Andrianello, S., Bossuyt, P., Bulow, R., Cardenas-Jaen, K., Cortegoso, P., Fontana, M., Haeberle, L., Heckler, M., Litvin, A., Mann, K., Michalski, C., Michl, P., Nappo, G., Perri, G., Persson, S., Scheufele, F., Sclafani, F., Schmidt, M., Venezia, L., Volker, F., Vullierm, M. P., Wusten, L., European Study Grp Cystic, Tum
Additional Information:	ISI Document Delivery No.: GC4DL Times Cited: 0 Cited Reference Count: 271 Del Chiaro, Marco Besselink, Marc G. Scholten, Lianne Bruno, Marco J. Cahen, Djuna L. Gress, Thomas M. van Hooft, Jeanin E. Lerch, Markus M. Mayerle, Julia Hackert, Thilo Satoi, Sohei Zerbi, Alessandro Cunningham, David De Angelis, Claudio Giovanni, Marc de-Madaria, Enrique Hegyi, Peter Rosendahl, Jonas Friess, Helmut Manfredi, Riccardo Levy, Philippe Real, Francisco X. Sauvanet, Alain Abu Hilal, Mohammed Marchegiani, Giovanni Esposito, Irene Ghaneh, Paula Engelbrecht, Marc R. W. Fockens, Paul van Huijgevoort, Nadine C. M. Wolfgang, Christopher Bassi, Claudio Gubergrits, Natalya B. Verbeke, Caroline Kloppel, Gunter Scarpa, Aldo Zamboni, Giuseppe Lennon, Anne Marie Sund, Malin Kartalis, Nikolaos Grenacher, Lars Falconi, Massimo Arnelo, Urban Kopchak, Kostantin V. Oppong, Kofi McKay, Colin Hauge, Truls Conlon, Kevin Adham, Mustapha Ceyhan, Guralp O. Salvia, Roberto Dervenis, Christos Allen, Peter Paye, Francois Bartsch, Detlef K. Lohr, Matthias Mutignani, Massimiliano Laukkarinen, Johanna Schulick, Richard Valente, Roberto Seufferlein, Thomas Capurso, Gabriele Siriwardena, Ajith Neoptolemos, John P. Pukitis, Aldis Segersvard, Ralf Aghdassi, A. Andrianello, S. Bossuyt, P. Bulow, R. Cardenas-Jaen, K. Cortegoso, P. Fontana, M. Haeberle, L. Heckler, M. Litvin, A. Mann, K. Michalski, C. Michl, P. Nappo, G. Perri, G. Persson, S. Scheufele, F. Sclafani, F. Schmidt, M. Venezia, L. Volker, F. Vullierm, M-P Wusten, L. UEG; EPC; E-AHPBA; EDS; ESGE; Cancerfonden Sweden The European Study Group on Cystic Tumours of the Pancreas is grateful to the UEG, EPC, E-AHPBA, EDS, ESGE and Cancerfonden Sweden for their support and thanks Professor Patrick Bossuyt, Academic Medical Center Amsterdam for the methodological support. 0 Bmj publishing group London 1468-3288
Uncontrolled Keywords:	papillary-mucinous-neoplasms international-consensus-guidelines fine-needle-aspiration single-institution experience term-follow-up solid pseudopapillary neoplasms confocal laser endomicroscopy liver-transplant recipients carbohydrate antigen 19-9 intraductal-papillary Gastroenterology & Hepatology
Research teams:	Clinical Units > Gastrointestinal Unit
Depositing User:	Barry Jenkins
Date Deposited:	30 Apr 2018 10:37
Last Modified:	30 Apr 2018 10:37
URI:	http://publications.icr.ac.uk/id/eprint/16794

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