Taylor, H., Hyer, S., Vini, L., Pratt, B., Cook, G., Harmer, C. (2004) Diagnostic I-131 whole body scanning after thyroidectomy and ablation for differentiated thyroid cancer. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 150 (5). pp. 649-653. ISSN 0804-4643

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Abstract

Diagnostic I-131 whole body scanning after thyroidectomy and ablation for differentiated thyroid cancer Objective: To assess the value of the diagnostic whole body I- 131 scan after thyroidectomy and I-131 ablation. Design: Retrospective analysis of all patients with differentiated thyroid cancer treated in one centre between 1990 and 2000. Results: A total of 153 consecutive patients who underwent diagnostic scanning following ablative therapy were identified. This diagnostic scan was positive in 20 patients (13%) and faintly positive in 16 patients (11%). The majority (117 patients) had negative scans. Of the 20 patients with positive scans, four received no further treatment. nine showed no abnormal uptake following a second ablative I-131 dose and seven had uptake in the thyroid bed (six) or in neck nodes (one) after repeat ablation. Outcome: In the group with positive scans. the four patients who received no further treatment and the nine with a negative second ablation scan remained disease free during follow-up. No patient with a positive diagnostic scan received additional I-131 therapy which would not otherwise have been given based on the clinical findings, serum thyroglobulin (Tg) values or the presence of anti-Tg antibodies. Ten of the patients with negative scans developed recurrent disease which was always detected clinically or by a rising serum Tg value. Conclusions: Diagnostic whole body I-131 scans add little extra information and in our experience do not influence patient management. They should be reserved for patients in whom serum Tg levels are unreliable because of the presence of antibodies or when there is clinical suspicion of tumour.

Item Type:	Article
All Authors:	Taylor, H., Hyer, S., Vini, L., Pratt, B., Cook, G., Harmer, C.
Uncontrolled Keywords:	Recombinant human tsh; serum thyroglobulin; follow-up; carcinoma; management; scans
Research teams:	Clinical Units > Thyroid Unit
Depositing User:	EPrints Services
Date Deposited:	10 Aug 2007 20:48
Last Modified:	13 Nov 2009 04:12
URI:	http://publications.icr.ac.uk/id/eprint/1850

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