Jonsson, V., Houlston, R. S., Catovsky, D., Yuille, M. R., Hilden, J., Olsen, J. H., Fajber, M., Brandt, B., Sellick, G., Allinson, R., Wiik, A. (2005) CLL family 'Pedigree 14' revisited: 1947-2004. LEUKEMIA, 19 (6). pp. 1025-1028. ISSN 0887-6924

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Abstract

CLL family 'Pedigree 14' revisited: 1947-2004 The notion that inherited predisposition contributes to the development of haematological malignancies is generally thought of as being a relatively new idea. However, Videbaek made a clear enunciation of such a hypothesis in 1947, from a study of tumour incidence in relatives of patients with different leukaemias. To gain further insight into inherited susceptibility to chronic lymphocytic leukaemia (CLL), we followed up the descendants of Videbaek's 'Pedigree 14' series of families. Using the Danish medical and pedigree databases, complete tracing of 222 descendants of the original 57 family members was achieved. To date, 10 family members have been diagnosed with CLL, one with T-cell lymphoma and 17 with nonhaematological cancers, including five with breast cancer. The detailed follow up of this family provides further support for inherited predisposition to CLL and illustrates the value of follow-up studies of previously published family material for genetic analyses.

Item Type:	Article
Authors (ICR Faculty only):	Houlston, Richard and Catovsky, Daniel
All Authors:	Jonsson, V., Houlston, R. S., Catovsky, D., Yuille, M. R., Hilden, J., Olsen, J. H., Fajber, M., Brandt, B., Sellick, G., Allinson, R., Wiik, A.
Uncontrolled Keywords:	chronic lymphocytic leukaemia; family; inheritance Chronic lymphocytic-leukemia; ataxia-telangiectasia; cancer; relatives; mutations; lymphoma; breast
Research teams:	ICR divisions > Genetics and Epidemiology > Molecular & Population Genetics ICR divisions > Molecular Pathology > Molecular & Population Genetics
Depositing User:	EPrints Services
Date Deposited:	10 Aug 2007 20:51
Last Modified:	10 Mar 2010 15:17
URI:	http://publications.icr.ac.uk/id/eprint/2157

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