Institute of Cancer Research Repository - Incidence, pattern and timing of brain metastases among patients with advanced breast cancer treated with trastuzumab

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Incidence, pattern and timing of brain metastases among patients with advanced breast cancer treated with trastuzumab

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Yau, T., Swanton, C., Chua, S., Sue, A., Walsh, G., Rostom, A., Johnston, S. R., O'Brien, M. E. R., Smith, I. E. (2006) Incidence, pattern and timing of brain metastases among patients with advanced breast cancer treated with trastuzumab. ACTA ONCOLOGICA, 45 (2). pp. 196-201. ISSN 0284-186X

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A copy of the full text may be available at: http://dx.doi.org/10.1080/02841860500486630

Abstract

Incidence, pattern and timing of brain metastases among patients with advanced breast cancer treated with trastuzumab We aim to investigate the incidence, patterns and timing of brain metastases in advanced breast cancer patients who have previously received trastuzumab. Eighty-seven patients who had received trastuzumab for advanced breast cancer from November 1999 to September 2003 at the Royal Marsden Hospital were assessed. With a median follow-up period of 11 months from commencing trastuzumab, 23 patients developed brain metastases (30% at 1 year; 95% CI 58-82%). Among 57 patients who had clinical benefits on trastuzumab, 12 (21%) patients developed first disease progression in brain with 75% of them had isolated CNS progression. Moreover, among patients who received trastuzumab as first line treatment, isolated brain metastases were the initial site of progression in 17% patients. Nearly all patients developed parenchymal brain disease. This study shows brain metastases are common phenomenon in HER2 positive advanced breast cancer patients receiving trastuzumab and also may implicate the brain as a sanctuary site for early relapse in this patient cohort.

Item Type:	Article
Authors (ICR Faculty only):	Johnston, Stephen and Smith, Ian
All Authors:	Yau, T., Swanton, C., Chua, S., Sue, A., Walsh, G., Rostom, A., Johnston, S. R., O'Brien, M. E. R., Smith, I. E.
Uncontrolled Keywords:	Nervous-system metastases; survival; therapy; erbb2; chemotherapy; association; combination; carcinoma; protein; genes
Research teams:	Clinical Units > Breast Unit
Date Deposited:	10 Aug 2007 20:58
Last Modified:	17 Nov 2009 14:14
URI:	http://publications.icr.ac.uk/id/eprint/3011

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