Imaging biochemistry: applications to breast cancer.
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Ronen, S. M., Leach, M. O.
(2001)
Imaging biochemistry: applications to breast cancer.
BREAST CANCER RESEARCH, 3 (1).
pp. 36-40.
ISSN 1465-542X
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Abstract
Imaging biochemistry: applications to breast cancer. The use of magnetic resonance spectroscopy (MRS) to investigate breast tumour biochemistry in vivo is reviewed. To this end, results obtained both from patients in vivo and from tumour extracts and model systems are discussed. An association has been observed between transformation and an increase in phosphomonoesters (PMEs) detected in the P-31 MRS spectrum, as well as an increase in choline-containing metabolites detected in the H-1 spectrum. A decrease in PME content after treatment is associated with response to treatment as assessed by tumour volume. Experiments in model systems aimed at understanding the underlying biochemical processes are presented, as well as data indicating the usefulness of MRS in monitoring the uptake and metabolism of some chemotherapeutic agents.
| Item Type: | Review Article |
|---|---|
| Authors (ICR Faculty only): | Leach, Martin and Ronen, Sabrina |
| All Authors: | Ronen, S. M., Leach, M. O. |
| Uncontrolled Keywords: | Choline; magnetic resonance spectroscopy (MRS); P-31 MRS; (1H) MRS; phosphomonoesters MAGNETIC-RESONANCE SPECTROSCOPY; PROTON MR SPECTROSCOPY; CHOSPHOLIPID-METABOLISM; IN-VIVO; MODEL SYSTEMS; TUMORS; CELLS; IN VIVO; PHARMACOKINETICS; EXPRESSION |
| Research teams: | ICR divisions > Radiotherapy and Imaging > Magnetic Resonance |
| Date Deposited: | 10 Aug 2007 21:03 |
| Last Modified: | 17 Dec 2014 11:36 |
| URI: | http://publications.icr.ac.uk/id/eprint/3550 |
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