Hudson, D. L. (2003) Prostate epithelial stem cell culture. CYTOTECHNOLOGY, 41 (2-3). pp. 189-196. ISSN 0920-9069

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Abstract

Prostate epithelial stem cell culture. The prostate gland is the site of the second most common cancer in men in the UK, with 9,280 deaths recorded in 2000. Another common disease of the prostate is benign prostatic hyperplasia and both conditions are believed to arise as a result of changes in the balance between cell proliferation and differentiation. There are three types of prostatic epithelial cell, proliferative basal, secretory luminal, and neuroendocrine. All three are believed to be derived from a common stem cell through differentiation along different pathways but the mechanisms behind these processes is poorly understood. In particular, there has until recently been very little information about prostate stem cell growth and differentiation. This review will discuss ways of distinguishing these prostate cell types using markers, such as keratins. Methods available for the culture of prostate epithelial cells and for the characterisation of stem cells both in monolayer and three-dimensional models are examined.

Item Type:	Review Article
Authors (ICR Faculty only):	Hudson, David
All Authors:	Hudson, D. L.
Uncontrolled Keywords:	benign prostatic hyperplasia; cancer; differentiation; epithelium; keratins; proliferation; proliferative heterogeneity; prostate; stem cells; BASAL CELLS; KERATIN EXPRESSION; IN-VITRO; NEUROENDOCRINE DIFFERENTIATION; CANCER; IDENTIFICATION; GROWTH; CYTOKERATINS; CARCINOMA; PATHWAYS
Research teams:	Closed research groups > Prostate Stem Cell
Date Deposited:	10 Aug 2007 21:04
Last Modified:	06 May 2015 12:53
URI:	http://publications.icr.ac.uk/id/eprint/3678

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