Kendall, A., Folkerd, E. J., Dowsett, M. (2007) Influences on circulating oestrogens in postmenopausal women: Relationship with breast cancer. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 103 (2). pp. 99-109. ISSN 0960-0760

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Abstract

Influences on circulating oestrogens in postmenopausal women: Relationship with breast cancer Sex hormones are intrinsically linked to the development and treatment of the majority of breast cancers. High oestradiol levels are associated with elevated breast cancer risk in the postmenopausal setting and are given increasing importance in determining chemoprevention target groups. This review aims to evaluate the impact of various lifestyle factors including body mass index, diet, smoking, and alcohol on normal physiological sex hormone profiles. The role of genetic polymorphisms is also discussed, and all are placed within the context of designing future epidemiological studies and breast cancer risk algorithms. (c) 2006 Elsevier Ltd. All rights reserved.

Item Type:	Review Article
Authors (ICR Faculty only):	Dowsett, Mitch
All Authors:	Kendall, A., Folkerd, E. J., Dowsett, M.
Uncontrolled Keywords:	oestrogen; postmenopausal; breast cancer Serum hormone concentrations; dietary-fat intake; body-mass index; cigarette-smoking; sex-hormones; genetic polymorphisms; replacement therapy; alcohol-consumption; steroid-hormones; bone loss
Research teams:	ICR divisions > Breast Cancer Research > Endocrinology ICR divisions > Molecular Pathology > Endocrinology
Date Deposited:	10 Aug 2007 21:06
Last Modified:	04 Feb 2014 14:29
URI:	http://publications.icr.ac.uk/id/eprint/3921

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