Vaidya, S. J., Hargrave, D., Saran, F., Britton, J., Soomal, R., Bouffet, E. (2007) Pattern of recurrence in paediatric malignant glioma: an institutional experience. JOURNAL OF NEURO-ONCOLOGY, 83 (3). pp. 279-284. ISSN 0167-594X

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Abstract

Background The purpose of this retrospective study was to investigate the pattern of recurrence in paediatric malignant gliomas. Material and methods: We reviewed the notes, diagnostic imaging and treatment charts of 30 consecutive paediatric patients (age less than 18 years at diagnosis, range 0.5-17 years) presenting with a malignant glioma presenting to the paediatric oncology unit at the Royal Marsden Hospital over a 10-year period. The imaging at the time of first relapse was compared with the initial diagnostic scans to define a relapse as local, marginal or distant. Results: Median follow-up was 13 months (range 1-99 months). Twenty-four of 30 patients (80%) showed evidence of progression with a median time to progression of 8.5 months (range 3-64 months). Thirteen out of 24 patients developed local or marginal recurrences while 11/24 patients recurred at distant sites as site of first relapse (46%). Conclusion: Our series suggests that the pattern of relapses in paediatric malignant gliomas could be different from that reported in adult studies as we observed a significant incidence of distant relapses. Larger prospective series need to be conducted to investigate the clinico-biological characteristics of the population at high risk for leptomeningeal dissemination.

Item Type:	Article
All Authors:	Vaidya, S. J., Hargrave, D., Saran, F., Britton, J., Soomal, R., Bouffet, E.
Uncontrolled Keywords:	malignant glioma; dissemination; metastases; glioblastoma; anaplastic astrocytoma; recurrence HIGH-GRADE ASTROCYTOMA; CHILDRENS-CANCER-GROUP; 8-DRUGS-IN-1-DAY REGIMEN; GLIOBLASTOMA-MULTIFORME; RANDOMIZED TRIAL; BRAIN-STEM; CHILDHOOD; DISSEMINATION; CHEMOTHERAPY; RADIOTHERAPY
Research teams:	Clinical Units > Paediatrics Unit
Depositing User:	Users 6 not found.
Date Deposited:	30 Dec 2007 13:45
Last Modified:	17 Sep 2009 08:58
URI:	http://publications.icr.ac.uk/id/eprint/5345

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