Molyneux, G., Regan, J., Smalley, M. J. (2007) Mammary stem cells and breast cancer. CMLS-Cellular and Molecular Life Sciences, 64 (24). pp. 3248-3260. ISSN 1420-682X

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Abstract

The mammary gland undergoes major developmental changes during puberty and pregnancy. It is thought that stem cells drive mammary gland development during puberty and are responsible for tissue maintenance as well as the major growth and remodelling that occurs with every pregnancy. The use of sophisticated cell separation procedures has facilitated the prospective isolation of mammary epithelial stem and differentiated cell subpopulations from the mouse mammary gland, while studies of primary human breast cancers have described subpopulations of tumourigenic cells capable of initiating tumour growth in immuno-compromised mice. These potential tumour 'stem cells' constitute an important therapeutic target population with respect to cancer therapy, as these are likely to be the cells which maintain tumour growth. Understanding the origin of these cells, their relationship to breast cancer subtypes, and how and why they differ from normal breast stem cells will lead to a revolution in tumour understanding, treatment and prevention.

Item Type:	Review Article
Authors (ICR Faculty only):	Smalley, Matthew
All Authors:	Molyneux, G., Regan, J., Smalley, M. J.
Uncontrolled Keywords:	breast; mammary; turnour; stem; estrogen receptor; CD24; CD44; CD133; Sca-1; field cancerisation ESTROGEN-RECEPTOR-ALPHA; TUMOR-INITIATING CELLS; TEMPLATE DNA STRANDS; IN-VITRO PROPAGATION; ADULT HUMAN BREAST; GLAND DEVELOPMENT; EPITHELIAL-CELLS; STEM/PROGENITOR CELLS; PROGESTERONE-RECEPTOR; MYOEPITHELIAL CELLS
Research teams:	Closed research groups > Mammary Stem Cells
Depositing User:	Users 10 not found.
Date Deposited:	20 Feb 2008 13:55
Last Modified:	11 Jan 2012 14:28
URI:	http://publications.icr.ac.uk/id/eprint/5614

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