Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 and BRCA2 mutation carriers
Friebel, T. M., Domchek, S. M., Neuhausen, S. L., Wagner, T., Evans, D. G., Isaacs, C., Garber, J. E., Daly, M. B., Eeles, R., Matloff, E., Tomlinson, G., Lynch, H. T., Tung, N., Blum, J. L., Weitzel, J., Rubinstein, W. S., Ganz, P. A., Couch, F., Rebbeck, T. R.
(2007)
Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 and BRCA2 mutation carriers.
CLINICAL BREAST CANCER, 7 (11).
pp. 875-882.
ISSN 1526-8209
Full text not available from this repository.
Abstract
Background: Women with BRCA1 or BRCA2 (BRCA1/2) mutations can reduce cancer incidence and mortality by using bilateral prophylactic oophorectomy (BPO) or bilateral prophylactic mastectomy (BPM). The availability of these risk-reduction strategies is an important consideration in the decision to undergo genetic testing. Patients and Methods: We evaluated the use of BPO and BPM in a prospective sample of 537 female BRCA1/2 mutation carriers from 17 centers in North America and Europe. These women were aged > 30 years, had no BPM, BPO, breast cancer, or ovarian cancer before the disclosure of their genetic test results and were followed for > 6 months. Results: Bilateral prophylactic oophorectomy is used significantly more frequently than BPM (55% vs. 21%; P < .001). Bilateral prophylactic oophorectomy was more common among women age >= 40 years compared with women aged < 40 years (68% vs. 43%; P < .001) and among porous women compared with nulliparous women (60% vs. 39%; P < .001). There was no difference in BPM (P = .83) or BPO (P = .09) in BRCA1 versus BRCA2 carriers. Multivariate models identified age and parity as a predictor of BPO in BRCA1 carriers; age and ovarian cancer family history in BRCA2 carriers; parity and ovarian cancer family history as a predictor of BPM in BRCA1 carriers; and smoking and ovarian cancer family history in BRCA2 carriers. Conclusion: Bilateral prophylactic oophorectomy is more commonly used than BPM in unaffected BRCA1/2 mutation carriers. Parity, age, and family history can also influence BPO and BPM uptake. Consistent with current recommendations, BPO is used by the majority of porous women aged > 40 years.
Item Type: | Article |
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Authors (ICR Faculty only): | Eeles, Rosalind |
All Authors: | Friebel, T. M., Domchek, S. M., Neuhausen, S. L., Wagner, T., Evans, D. G., Isaacs, C., Garber, J. E., Daly, M. B., Eeles, R., Matloff, E., Tomlinson, G., Lynch, H. T., Tung, N., Blum, J. L., Weitzel, J., Rubinstein, W. S., Ganz, P. A., Couch, F., Rebbeck, T. R. |
Uncontrolled Keywords: | genetic testing; hereditary breast cancer; surgery BREAST-CANCER RISK; SALPINGO-OOPHORECTOMY; OVARIAN-CANCER; PREVENTIVE MEASURES; GENE MUTATION; WOMEN; SURGERY; POPULATION |
Research teams: | ICR divisions > Genetics and Epidemiology > Oncogenetics ICR divisions > Radiotherapy and Imaging > Oncogenetics |
Depositing User: | Users 10 not found. |
Date Deposited: | 10 Jun 2008 10:54 |
Last Modified: | 10 Feb 2010 11:50 |
URI: | http://publications.icr.ac.uk/id/eprint/6286 |
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