Caveolin 1 and caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype
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Elsheikh, S. E., Green, A. R., Rakha, E. A., Samaka, R. M., Ammar, A. A., Powe, D., Reis-Filho, J. S., Ellis, I. O.
(2008)
Caveolin 1 and caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype.
BRITISH JOURNAL OF CANCER, 99 (2).
pp. 327-334.
ISSN 0007-0920
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Abstract
Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid and cholesterol-rich invaginations of the plasma membrane involved in vesicular trafficking and signal transduction. Over the recent years there has been controversy about their role in breast cancer and their suitability as markers of basal-like phenotype. Caveolin-1 and CAV2 protein expression was assessed on a tissue microarray containing 880 unselected invasive breast cancer cases, by means of immunohistochemistry. Caveolin-1 and CAV2 expression was observed in 13.4 and 5.9% of all breast cancer, respectively. Their expression was strongly associated with high histological grade, lack of steroid hormone receptor positivity (ER and PR), and expression of basal markers (basal cytokeratins, P63, P-cadherin). Furthermore, there was a significant association between CAV1 and CAV2 expression and basal-like phenotype. On univariate analysis only CAV2 had a prognostic impact on breast cancer-specific survival; however, this was not independent from other traditional markers on multivariate analysis. Our results demonstrate that both CAV1 and CAV2 are associated with basal-like phenotype. Further studies are warranted to determine whether they play an oncogenic role in basal-like/triple-negative breast cancer development or are just surrogate markers for this subgroup.
| Item Type: | Article |
|---|---|
| Authors (ICR Faculty only): | Reis-Filho, Jorge |
| All Authors: | Elsheikh, S. E., Green, A. R., Rakha, E. A., Samaka, R. M., Ammar, A. A., Powe, D., Reis-Filho, J. S., Ellis, I. O. |
| Uncontrolled Keywords: | caveolin 1; caveolin 2; immunohistochemistry; breast; basal-like SITU HYBRIDIZATION ANALYSIS; SQUAMOUS-CELL CARCINOMA; D7S522 LOCUS 7Q31.1; PROSTATE-CANCER; PROGNOSTIC MARKERS; POOR-PROGNOSIS; LUNG-CANCER; NULL MICE; EXPRESSION; GENE |
| Research teams: | Closed research groups > Molecular Pathology |
| Depositing User: | Users 10 not found. |
| Date Deposited: | 12 Aug 2008 14:28 |
| Last Modified: | 17 Dec 2014 11:40 |
| URI: | http://publications.icr.ac.uk/id/eprint/6678 |
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