Strimpakos, A., Saif, M. W., Syrigos, K. N. (2008) Pancreatic cancer: from molecular pathogenesis to targeted therapy. CANCER AND METASTASIS REVIEWS, 27 (3). pp. 495-522. ISSN 0167-7659

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Abstract

Pancreatic cancer is a deadly malignancy with still high mortality and poor survival despite the significant advances in understanding, diagnosis, and access to conventional and novel treatments. Though cytotoxic chemotherapy based on the purine analogue gemcitabine remains the standard approach in adjuvant and palliative setting the need for novel agents aiming at the main pathophysiological abnormalities and molecular pathways involved remains soaring. So far, evidence of clinical benefit, though small, exists only from the addition of the targeted agent erlotinib on the standard gemcitabine chemotherapy. Apart from the popular monoclonal antibodies and small molecules tyrosine kinase inhibitors, other novel compounds being tested in preclinical and clinical studies target mTOR, NF-kappa B, proteasome and histone deacetylase. These new drugs along with gene therapy and immunotherapy, which are also under clinical evaluation, may alter the unfavorable natural course of this disease. In this review we present the main pathophysiological alterations met in pancreatic cancer and the results of the florid preclinical and clinical research with regards to the targeted therapy associated to these abnormalities.

Item Type:	Review Article
All Authors:	Strimpakos, A., Saif, M. W., Syrigos, K. N.
Uncontrolled Keywords:	molecular pathophysiology; pancreatic adenocarcinoma; monoclonal antibodies; tyrosine kinase inhibitors; novel agents; targeted therapies GROWTH-FACTOR RECEPTOR; FACTOR-KAPPA-B; HISTONE DEACETYLASE INHIBITOR; FOCAL ADHESION KINASE; PHASE-I TRIAL; TRAIL-INDUCED APOPTOSIS; ADVANCED SOLID TUMORS; CELL-CYCLE ARREST; REVERSE-TRANSCRIPTASE PROMOTER; FARNESYL-PROTEIN TRANSFERASE
Research teams:	Clinical Units > Other Royal Marsden Services/Clinical Units
Depositing User:	Users 10 not found.
Date Deposited:	08 Sep 2008 10:05
Last Modified:	30 Sep 2009 10:47
URI:	http://publications.icr.ac.uk/id/eprint/6921

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