Tan, D. S. P., Lambros, M. B. K., Marchio, C., Reis-Filho, J. S. (2008) ESR1 amplification in endometrial carcinomas: hope or hyperbole? JOURNAL OF PATHOLOGY, 216 (3). pp. 271-274. ISSN 0022-3417

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Abstract

The ESR1 gene maps 6q25 and encodes for oestrogen receptor alpha, which has been shown to play, a pivotal role in the development of breast and endometrial cancer. It has recently, been reported that oestrogen receptor alpha expression may be driven in some cases by ESR1 gene amplification and that this phenomenon may, be an early event in breast and endometrial carcinogenesis. Although copy number gains of 6q have been reported by, several groups, their prevalence, association with oestrogen receptor alpha expression, and clinical implications have been a matter of controversy. Here we discuss the key issues regarding the methods employed in the identification of ESR1 amplification, and briefly review the current literature and recent controversies on the subject of ESR1 amplification in endometrial and breast cancers. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Item Type:	Editorial
Authors (ICR Faculty only):	Reis-Filho, Jorge
All Authors:	Tan, D. S. P., Lambros, M. B. K., Marchio, C., Reis-Filho, J. S.
Uncontrolled Keywords:	ESR1; oestrogen receptor; fluorescence in situ hybridization; 6q; amplification; breast; endometrium; neoplasia COMPARATIVE GENOMIC HYBRIDIZATION; BREAST-CANCER; GENETIC IMBALANCES; PRECURSOR LESIONS; ABERRATIONS; FREQUENT; CGH
Research teams:	Closed research groups > Molecular Pathology
Depositing User:	Users 10 not found.
Date Deposited:	17 Dec 2008 11:54
Last Modified:	21 Feb 2014 15:30
URI:	http://publications.icr.ac.uk/id/eprint/7299

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