Rakha, E. A., El-Sayed, M. E., Reis-Filho, J., Ellis, I. O. (2009) Patho-biological aspects of basal-like breast cancer. BREAST CANCER RESEARCH AND TREATMENT, 113 (3). pp. 411-422. ISSN 0167-6806

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Abstract

Breast cancer comprises a remarkably diverse group of diseases in terms of presentation, morphology, molecular profile and response to therapy. Recent gene expression profiling of breast cancer has identified specific molecular subtypes of clinical significance. Basal-like cancers (BLC) comprise a group of tumours that are characterised by an expression signature similar to that of the basal/myoepithelial cells of the breast and cluster together with BRCA1 associated tumours. Although BLC has fascinated oncologists and scientists alike due to its enigmatic clinical and pathological parameters, there is no consensus about the definition and method of identification in routine practice of this rather heterogeneous group of cancers. Furthermore, the prognostic significance of BLCs and response to specific chemotherapy regimens are still a matter debate. In this review, we discuss the molecular and morphological features, prognostic significance of BLC, and explore its impact on the concept of the breast cancer stem cell.

Item Type:	Review Article
Authors (ICR Faculty only):	Reis-Filho, Jorge
All Authors:	Rakha, E. A., El-Sayed, M. E., Reis-Filho, J., Ellis, I. O.
Uncontrolled Keywords:	Breast cancer; Basal-like; Definition; Morphology; Prognosis CARCINOMA IN-SITU; GENE-EXPRESSION SIGNATURE; INVASIVE DUCTAL CARCINOMA; ESTROGEN-RECEPTOR; STEM-CELLS; EPITHELIAL PHENOTYPE; MEDULLARY CARCINOMA; MYOEPITHELIAL DIFFERENTIATION; IMMUNOHISTOCHEMICAL MARKERS; MALIGNANT MYOEPITHELIOMA
Research teams:	Closed research groups > Molecular Pathology
Depositing User:	Users 10 not found.
Date Deposited:	16 Feb 2009 12:40
Last Modified:	24 Feb 2014 14:34
URI:	http://publications.icr.ac.uk/id/eprint/7493

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