Lord, C. J., Ashworth, A. (2007) RAD51, BRCA2 and DNA repair: a partial resolution. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 14 (6). pp. 461-462. ISSN 1545-9985

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Abstract

Cooperation between the DNA recombinase RAD51 and the breast cancer susceptibility protein BRCA2 is crucial for the repair of double-strand DNA breaks. Two papers provide new insight into the BRCA2-RAD51 interaction, revealing two different sets of motifs within BRCA2 that bind structurally distinct forms of RAD51. The balance between these interactions seems to be crucial for the function of BRCA2 in DNA repair.

Item Type:	Editorial
Authors (ICR Faculty only):	Ashworth, Alan and Lord, Chris
All Authors:	Lord, C. J., Ashworth, A.
Uncontrolled Keywords:	OVARIAN-CANCER; MAINTENANCE; BREAST
Research teams:	ICR divisions > Breast Cancer Research > Gene Function ICR divisions > Molecular Pathology > Gene Function
Depositing User:	Users 10 not found.
Date Deposited:	01 May 2009 15:35
Last Modified:	10 Feb 2010 11:51
URI:	http://publications.icr.ac.uk/id/eprint/7877

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