Di Bernardo, M. C., Matakidou, A., Eisen, T., Houlston, R. S., GELCAPS Consortium, [Group Author] (2009) Plasminogen activator inhibitor variants PAI-1 A15T and PAI-2 S413C influence lung cancer prognosis. LUNG CANCER, 65 (2). pp. 237-241. ISSN 0169-5002

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Abstract

The plasminogen pathway plays an important role in the behavior of many tumors including lung cancer. Hence genetic variants encoding plasminogen activator (PLAU), plasminogen receptor (PLAUR), plasminogen activator inhibitor 1 (PAI-1) and plasminogen activator inhibitor 2 (PAI-2) may contribute to lung cancer prognosis. To investigate this proposition we genotyped PAI-1 A15T, PLAU L141P, PLAUR L317P and PAI-2 S413C variants in 698 patients with lung cancer, 522 with non-small cell (NSCLC) and 176 with small cell lung cancer (SCLC). PAI-1 A15T was significantly associated with overall survival (OS), with carriers of variant alleles having a worse prognosis (hazard ratio (HR) = 1.14; 95% confidence interval [CI]: 1.03-1.26). An association was also detected between OS in NSCLC and carrier status for PAI-2 413C (HR = 1.13; 95% Cl: 1.01-1.24). These common genetic variants identified warrant further evaluation as promising prognostic markers of patient outcome. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Article
Authors (ICR Faculty only):	Houlston, Richard
All Authors:	Di Bernardo, M. C., Matakidou, A., Eisen, T., Houlston, R. S., GELCAPS Consortium, [Group Author]
Uncontrolled Keywords:	Lung cancer; Plasminogen; Polymorphism; Prognosis;BREAST-CANCER; COLORECTAL-CANCER; METASTASIS; MARKER; SYSTEM; STATISTICS; RELEVANCE; SURVIVAL; INVASION; RECEPTOR
Funding Acknowledgement:	NCRN ; HEAL ; Sanofi-Aventis ; Allan J Lerner Fund ; Cancer Research UK
Funding Text:	We are grateful to patients for their participation. Funding for this work was undertaken with support primarily from Cancer Research UK. Additional support was provided by NCRN, HEAL and Sanofi-Aventis. Athena Matakidou was the recipient of a clinical research fellowship from the Allan J Lerner Fund.
Research teams:	ICR divisions > Genetics and Epidemiology > Molecular & Population Genetics ICR divisions > Molecular Pathology > Molecular & Population Genetics
Depositing User:	Users 10 not found.
Date Deposited:	24 Aug 2009 14:16
Last Modified:	10 Feb 2010 11:51
URI:	http://publications.icr.ac.uk/id/eprint/8592

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