Mai, P. L., Chen, B. E., Tucker, K., Friedlander, M., Phillips, K., Hogg, D., Jewett, M. A. S., Bodrogi, I., Geczi, L., Olah, E., Heimdal, K., Fossa, S. D., Nathanson, K. L., Korde, L., Easton, D. F., Dudakia, D., Huddart, R., Stratton, M. R., Bishop, D. T., Rapley, E. A., Greene, M. H. (2009) Younger age-at-diagnosis for familial malignant testicular germ cell tumor. FAMILIAL CANCER, 8 (4). pp. 451-456. ISSN 1389-9600

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Abstract

One of the clinical hallmarks of hereditary cancer susceptibility disorders is a younger-than-usual age at diagnosis. Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but data on whether familial TGCT cases are diagnosed at an earlier age are inconclusive. Here we compared the age at diagnosis of familial TGCT cases with that of population cases in several countries. Familial TGCT is defined as affected individuals from families with a parts per thousand yen2 cases of TGCT. Age at diagnosis of familial cases from the United States, Canada, United Kingdom, Australia and New Zealand, Norway, and Hungary was compared to cases identified in population-based cancer registries from the respective country, using the generalized estimation equation method. Age at diagnosis was statistically significantly younger for familial TGCT cases from North America (P = 0.024), the United Kingdom (P < 0.0001), and Australia and New Zealand (P = 0.0033) compared with population cases. When stratified by histology, the difference in age at diagnosis distribution between familial and population cases was observed for seminoma cases from North America (P = 0.002) and the United Kingdom (P < 0.0001) and non-seminoma cases from the United Kingdom (P = 0.029) and Australia and New Zealand (P = 0.0023). In summary, we found that the age at diagnosis for familial TGCT cases is, on the average, 2-3 years younger than that for the population cases in North America, United Kingdom, and Australia and New Zealand. The younger age at diagnosis might be suggestive of a genetic basis for familial TGCT.

Item Type:	Article
Authors (ICR Faculty only):	Huddart, Robert and Rapley, Liz and Stratton, Mike
All Authors:	Mai, P. L., Chen, B. E., Tucker, K., Friedlander, M., Phillips, K., Hogg, D., Jewett, M. A. S., Bodrogi, I., Geczi, L., Olah, E., Heimdal, K., Fossa, S. D., Nathanson, K. L., Korde, L., Easton, D. F., Dudakia, D., Huddart, R., Stratton, M. R., Bishop, D. T., Rapley, E. A., Greene, M. H.
Uncontrolled Keywords:	Age at diagnosis; Familial; Non-seminoma; Population-based testicular cancer; Seminoma; Testicular germ cell tumor;SUSCEPTIBILITY GENES; CANCER; POPULATION; RISK
Funding Acknowledgement:	National Cancer Institute, National Institutes of Health [N02-CP-11019, N02-CP-65504]
Funding Text:	We would like to thank Dr. Parry Guilford for his contribution to the familial TGCT cases. We also thank Istvan Gaudi (Cancer Registry of National Institute of Oncology, Budapest, Hungary) and Sue Westlake (Social & Health Analysis & Reporting Division, Office for National Statistics, UK) for their contribution from the cancer registries. This research was funded in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, and supported by contracts N02-CP-11019 and N02-CP-65504 with Westat, Incorporated. The authors have no conflict of interest or financial disclosures to report.
Research teams:	ICR divisions > Radiotherapy and Imaging > Clinical Academic Radiotherapy (Huddart) ICR divisions > Breast Cancer Research > Genetic Susceptibility ICR divisions > Genetics and Epidemiology > Genetic Susceptibility
Depositing User:	Users 10 not found.
Date Deposited:	13 Nov 2009 11:38
Last Modified:	20 Apr 2010 10:19
URI:	http://publications.icr.ac.uk/id/eprint/9027

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