Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane
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Whelligan, D. K., Thomson, D. W., Taylor, D., Hoelder, S.
(2010)
Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane.
JOURNAL OF ORGANIC CHEMISTRY, 75 (1).
pp. 11-15.
ISSN 0022-3263
Full text not available from this repository.
Abstract
An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.
Item Type: | Article |
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Authors (ICR Faculty only): | Hoelder, Swen |
All Authors: | Whelligan, D. K., Thomson, D. W., Taylor, D., Hoelder, S. |
Uncontrolled Keywords: | CROSS-COUPLING REACTIONS; SUZUKI-MIYAURA REACTION; HIGHLY-ACTIVE CATALYST; CONVENIENT SYNTHESIS; KINASE INHIBITORS; ARYL CHLORIDES; REACTIVITY; AZAINDOLES; DESIGN; 7-AZAINDOLES |
Funding Acknowledgement: | NHS ; Cancer Research UK [C309/A8274] |
Funding Text: | We acknowledge NHS funding to the NIHR Biomedical Research Centre and funding from Cancer Research UK program Grant No. C309/A8274. We also thank Dr. Amin Mirza, Mr. Mcirion Richards, and Dr. Maggie Liu for their help with LC, NMR, and mass spectrometry. |
Research teams: | ICR divisions > Cancer Therapeutics > Medicinal Chemistry 4 |
Depositing User: | Users 10 not found. |
Date Deposited: | 08 Jan 2010 14:38 |
Last Modified: | 08 Jan 2010 14:38 |
URI: | http://publications.icr.ac.uk/id/eprint/9198 |
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