Broderick, P., Cunningham, D., Vijayakrishnan, J., Cooke, R., Ashworth, A., Swerdlow, A., Houlston, R. (2010) IRF4 polymorphism rs872071 and risk of Hodgkin lymphoma. BRITISH JOURNAL OF HAEMATOLOGY, 148 (3). pp. 413-415. ISSN 0007-1048

Full text not available from this repository.

Abstract

P>The reciprocal familial risk between chronic lymphocytic leukaemia (CLL) and Hodgkin lymphoma (HL) suggests genetic variants with pleiotropic effects may influence the risk of both CLL and HL. We have recently shown that the IRF4 variant rs872071 influences CLL risk. To examine if rs872071 genotype is associated with HL risk we genotyped two case-control series (totalling, 529 and 2192, respectively). This analysis provides evidence that IRF4 rs872071 influences HL risk; Odds Ratio = 1 center dot 21 (95% confidence interval: 1 center dot 05-1 center dot 39, P = 0 center dot 009) and highlights the importance of inherited variation in B-cell developmental genes in the development of HL.

Item Type:	Article
Authors (ICR Faculty only):	Ashworth, Alan and Houlston, Richard and Swerdlow, Anthony and Cunningham, David
All Authors:	Broderick, P., Cunningham, D., Vijayakrishnan, J., Cooke, R., Ashworth, A., Swerdlow, A., Houlston, R.
Uncontrolled Keywords:	IRF4; Hodgkin lymphoma; susceptibility; single nucleotide polymorphism; B-cell;CHRONIC LYMPHOCYTIC-LEUKEMIA; FAMILY-CANCER DATABASE; PREDISPOSITION; SUSCEPTIBILITY; DISEASE
Funding Acknowledgement:	Leukaemia Research ; Cancer Research UK ; NHS
Funding Text:	We are grateful to the patients and their clinicians who participated in this study -specifically Dr G. Anghel, Lincoln Hospital; Dr B. Attock, North Devon District Hospital, Barnstaple; Dr S. Awward, Royal Shrewsbury Hospital; Dr J. Barrett, Royal Berkshire Hospital, Reading; Dr A. Bates, Southampton General Hospital; Dr A. Bell, Poole Hospital; Dr K. Benstead, Cheltenham General Hospital,; Dr E.M. Bissell, Nottingham University Hospital; Dr A. Biswas, Royal Preston Hospital; Dr N. Blesing, Great Western Hospital, Swindon; Prof M. Brada, Royal Marsden Hospital; Dr C. Brammer, New Cross Hospital, Northampton; Dr J.E.S. Brock, Clatterbridge Centre for Oncology; Dr A.M. Brunt, University Hospital of North Staffs; Dr P. Coates, Queen Elizabeth Hospital, King's Lynn; Dr M.P. Collinson, Royal Cornwall Hospital, Tresliske Prof. N. Davidson, Essex County Hospital, Colchester; Dr S. Davies, North Middlesex; Dr S. Falk, Bristol Haematology & Oncology Centre; Prof. I Fentiman, Guy's Hospital; Dr E. Gallop-Evans, Velindre Hospital, Cardiff; Dr A. Garcia; Glan Clwyd Hospital, Bodelwyddan, Rhyl; Dr D. Gilson; Cookridge Hospital, Leeds; Dr A. Goodman, Royal Devon & Exeter Hospital; Mr G. Gui, Royal Marsden Hospital; Prof B.W. Hancock, Weston Park Hospital, Sheffield; Dr A. Harnett, Norfolk & Norwich Hospital; Dr S. J. Harris, St. Thomas' Hospital, London; Prof. A. Horwich, Royal Marsden Hospital; Prof. P. Hoskin, Mount Vernon Hospital; Dr C. Irwin, University Hospital, Coventry; Dr S.A. Kelly, Derriford Hospital, Plymouth; Dr J. Kingston, Great Ormond Street Hospital; Dr C. Knechtli, Royal United Hospital, Bath; Dr G. Levitt, Great Ormond Street Hospital; Prof. D. Linch, University College London Hospitals; Prof. A. Lister, St. Bartholomew's; Dr H. Lucraft, Northern Centre for Cancer Care, Freeman Hospital; Dr Z. Maung, James Cook Hospital; Dr C. McNamara, Royal Free Hospital; Dr J. Morgan, Ipwich, Dr P. Murray, Colchester General; Dr H. O'Brien, Cumberland Royal Infirmary; Dr A. O'Callaghan, St. Mary's Hospital, Portsmouth; Dr N. O'Connor, Shrewsbury Hospital; Dr R. Patmore, Hull Royal Infirmary; Dr M. Persic, Derby City General Hospital; Dr C. Pocock, Kent & Canterbury Hospital; Dr H. Price, Taunton; Prof. K. Pritchard-Jones, Royal Marsden Hospital; Prof. J. Radford, Christie Hospital; Dr G. Ross, Royal Marsden Hospital; Dr J R Y Ross, Kettering General Hospital; Dr A Salisbury, Churchill Hospital, Oxford; Dr M. Savage, Charing Cross Hospital/Hammersmith Hospital; Dr J. Simpson, Royal Sussex County Hospital, Brighton; Prof I Smith, Royal Marsden Hospital; Dr A Stevens, Queen Elizabeth Hospital, Birmingham; P, Dr S. Rassam, Kent & Canterbury Hospital; Prof R. E. Taylor, Singleton Hospital, Swansea; Dr G. Thomas, Leicester Royal Infirmary; Dr C. Trask, Southend Hospital; Dr J. Treleaven, Royal Marsden Hospital; Dr Z Volkova, North Devon District Hospital, Barnstaple; Dr N West, Whitehaven Hospital; Dr S. Whitaker, Royal Surrey County Hospital; Dr M. Williams, Addenbrooke's Hospital, Cambridge; Prof J. Yarnold, Royal Marsden Hospital. The work was supported by grants from Leukaemia Research and Cancer Research UK, and the data collection by Breakthrough Breast Cancer and the European Union. We acknowledge NHS funding to the NIHR Biomedical Research Centre.
Research teams:	ICR divisions > Breast Cancer Research > Gene Function ICR divisions > Molecular Pathology > Gene Function ICR divisions > Breast Cancer Research > Aetiological Epidemiology ICR divisions > Genetics and Epidemiology > Aetiological Epidemiology ICR divisions > Genetics and Epidemiology > Molecular & Population Genetics ICR divisions > Molecular Pathology > Molecular & Population Genetics
Depositing User:	Users 10 not found.
Date Deposited:	01 Feb 2010 09:26
Last Modified:	10 Feb 2010 11:52
URI:	http://publications.icr.ac.uk/id/eprint/9248

Actions (login required)

View Item