Messiou, C., deSouza, N. M. (2010) Diffusion Weighted Magnetic Resonance Imaging of metastatic bone disease: A biomarker for treatment response monitoring. CANCER BIOMARKERS, 6 (1). pp. 21-32. ISSN 1574-0153

PDF 9353PV.pdf Download (288kB)

Abstract

Diffusion Weighted Magnetic Resonance Imaging (DW-MRI) combined with conventional MRI can provide a whole body assessment of metastatic bone disease, improved lesion detection compared to other imaging techniques and a direct quantitative assessment of treatment response. In bone marrow, the presence of fat and bone trabeculae and their changing contributions with disease progression and response to treatment present unique challenges for data acquisition and image interpretation. This article discusses these challenges and reviews the potential of DW-MRI to provide a biomarker of response in metastatic bone disease.

Item Type:	Article
Authors (ICR Faculty only):	Desouza, Nandita
All Authors:	Messiou, C., deSouza, N. M.
Uncontrolled Keywords:	Tumour therapy; cancer; diffusion; bone; magnetic resonance imaging;VERTEBRAL COMPRESSION FRACTURES; POSITRON-EMISSION-TOMOGRAPHY; CANCER CLINICAL-TRIALS; RISK PROSTATE-CANCER; TUMOR RESPONSE; BREAST-CANCER; AXIAL SKELETON; MRI; MARROW; PET
Funding Acknowledgement:	CRUK ; EPSRC Cancer Imaging Centre ; Department of Health (England) [C1060/A10334]; NHS ; NIHR Biomedical Research Centre
Funding Text:	We acknowledge the support received for the CRUK and EPSRC Cancer Imaging Centre in association with the MRC and Department of Health (England) grant C1060/A10334 and also NHS funding to the NIHR Biomedical Research Centre.
Research teams:	ICR divisions > Radiotherapy and Imaging > Magnetic Resonance
Depositing User:	Users 10 not found.
Date Deposited:	05 Mar 2010 10:46
Last Modified:	17 Dec 2014 11:44
URI:	http://publications.icr.ac.uk/id/eprint/9353

Actions (login required)

View Item