Institute of Cancer Research Repository - Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas)

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Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas)

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Marchio, C., Weigelt, B., Reis-Filho, J. S. (2010) Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas). JOURNAL OF CLINICAL PATHOLOGY, 63 (3). pp. 220-228. ISSN 0021-9746

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Abstract

Adenoid cystic carcinoma (AdCC) is a tumour with myoepithelial differentiation and characterised by the presence of a dual population of basaloid and luminal cells arranged in specific growth patterns. These tumours, regardless of the anatomical site, are characterised by expression of the proto-oncogene and therapeutic target c-KIT, and seem to harbour a specific chromosomal translocation t(6;9) leading to the fusion gene MYB-NFIB and overexpression of the oncogene MYB. However, the clinical behaviour of salivary gland and breast AdCC differs; while salivary gland lesions have a relatively high proclivity to metastasise, patients with breast AdCCs have an excellent outcome. Here the clinical, morphological and molecular features, and potential therapeutic targets of salivary gland and breast AdCCs are reviewed.

Item Type:	Review Article
Authors (ICR Faculty only):	Reis-Filho, Jorge
All Authors:	Marchio, C., Weigelt, B., Reis-Filho, J. S.
Uncontrolled Keywords:	LOW-GRADE ADENOCARCINOMA; TUMOR-SUPPRESSOR GENES; C-KIT; MICROGLANDULAR ADENOSIS; IMATINIB MESYLATE; CLINICOPATHOLOGICAL CORRELATION; PROLIFERATIVE ACTIVITY; CANCER CLASSIFICATION; MOLECULAR PORTRAITS; CLINICAL-COURSE
Funding Acknowledgement:	Breakthrough Breast Cancer ; Ricerca Sanitaria Finalizzata Regione Piemonte ; Cancer Research UK ; NHS
Funding Text:	This study was funded by Breakthrough Breast Cancer and Ricerca Sanitaria Finalizzata Regione Piemonte 2009. BW is funded by a Cancer Research UK fellowship. NHS funding to the NIHR Biomedical Research Centre is also acknowledged.
Research teams:	Closed research groups > Molecular Pathology
Depositing User:	Users 10 not found.
Date Deposited:	22 Mar 2010 10:49
Last Modified:	19 Feb 2014 15:57
URI:	http://publications.icr.ac.uk/id/eprint/9380

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