Liu, Y., Shete, S., Hosking, F. J., Robertson, L. B., Bondy, M. L., Houlston, R. S. (2010) New Insights Into Susceptibility to Glioma. ARCHIVES OF NEUROLOGY, 67 (3). pp. 275-278. ISSN 0003-9942

Full text not available from this repository.

Abstract

The study of inherited susceptibility to cancer has been one of the most informative areas of research in the past decade. Most of the cancer genetics studies have been focused on the common tumors such as breast and colorectal cancers. As the allelic architecture of these tumors is unraveled, research attention is turning to other rare cancers such as glioma, which are also likely to have a major genetic component as the basis of their development. In this brief review we discuss emerging data on glioma whole genome-association searches to identify risk loci. Two glioma genome-wide association studies have so far been reported. Our group identified 5 risk loci for glioma susceptibility( TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872). Wrensch and colleagues provided further evidence to 2 risk loci( CDKN2B rs1412829 and RTEL1 rs6010620) for GBM and anaplastic astrocytoma. Although these data provide the strongest evidence to date for the role of common low-risk variants in the etiology of glioma, the single-nucleotide polymorphisms identified alone are unlikely to be candidates for causality. Identifying the causal variant at each specific locus and its biological impact now poses a significant challenge, contingent on a combination of fine mapping and functional analyses. Finally, we hope that a greater understanding of the biological basis of the disease will lead to the development of novel therapeutic interventions. Arch Neurol. 2010; 67( 3): 275-278

Item Type:	Review Article
Authors (ICR Faculty only):	Houlston, Richard
All Authors:	Liu, Y., Shete, S., Hosking, F. J., Robertson, L. B., Bondy, M. L., Houlston, R. S.
Uncontrolled Keywords:	GENOME-WIDE ASSOCIATION; CANCER; VARIANTS; RISK; LOCI; COMMON; DELETION; 8Q24
Funding Acknowledgement:	Bobby Moore Fund in England [C1298/A8362]; National Institutes of Health in the United States [5R01CA119215, 5R01CA070917]; American Brain Tumor Association ; National Brain Tumor Society ; Wellcome Trust
Funding Text:	This study was supported by grant C1298/A8362 from the Bobby Moore Fund in England and grants 5R01CA119215 and 5R01CA070917 from the National Institutes of Health in the United States; the American Brain Tumor Association; the National Brain Tumor Society; and the Wellcome Trust (principal funding).
Research teams:	ICR divisions > Genetics and Epidemiology > Molecular & Population Genetics ICR divisions > Molecular Pathology > Molecular & Population Genetics
Depositing User:	Users 10 not found.
Date Deposited:	22 Mar 2010 10:07
Last Modified:	22 Mar 2010 10:07
URI:	http://publications.icr.ac.uk/id/eprint/9390

Actions (login required)

View Item