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Closed research groups > Human Biomonitoring & Carcinogen Activation

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      • Human Biomonitoring & Carcinogen Activation (165)
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Number of items at this level: 158.

A

Arlt, V. M. (2005) 3-nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence. MUTAGENESIS, 20 (6). pp. 399-410. ISSN 0267-8357

Arlt, V. M., Pfohl-Leszkowicz, A., Cosyns, J. P., Schmeiser, H. H. (2001) Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 494 (1–2). pp. 143-150. ISSN 1383-5718

Arlt, V. M., Alunni-Perret, V., Quatrehomme, G., Ohayon, P., Albano, L., Gaid, H., Michiels, J. F., Meyrier, A., Cassuto, E., Wiessler, M., Schmeiser, H. H., Cosyns, J. P. (2004) Aristolochic acid (AA)-DNA adduct as a marker of AA exposure and risk factor for AA nephropathy-associated cancer. INTERNATIONAL JOURNAL OF CANCER, 111 (6). pp. 977-980. ISSN 0020-7136

Arlt, V. M., Stiborova, M., Schmeiser, H. H. (2002) Aristolochic acid as a probable human cancer hazard in herbal remedies a review. MUTAGENESIS, 17 (4). pp. 265-277. ISSN 0267-8357

Lebeau, C., Arlt, V. M., Schmeiser, H. H., Boom, A., Verroust, P. J., Devuyst, O. (2001) Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells. KIDNEY INTERNATIONAL, 60 (4). pp. 1332-1342. ISSN 0085-2538

Wang, Y. Y., Meng, F. X., Arlt, V. M., Mei, N., Chen, T., Parsons, B. L. (2011) Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction. MUTAGENESIS, 26 (5). pp. 619-628. ISSN 0267-8357

Wang, T., Gavin, H. M., Arlt, V. M., Lawrence, B. P., Fenton, S. E., Medina, D., Vorderstrasse, B. A. (2011) Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors. INTERNATIONAL JOURNAL OF CANCER, 128 (7). pp. 1509-1523. ISSN 0020-7136

Schmeiser, H. H., Stiborova, M., Arlt, V. M. (2009) Chemical and molecular basis of the carcinogenicity of Aristolochia plants. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 12 (1). pp. 141-148. ISSN 1367-6733

Martinek, V., Kubickova, B., Arlt, V. M., Frei, E., Schmeiser, H. H., Hudecek, J., Stiborova, M. (2011) Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases. NEUROENDOCRINOLOGY LETTERS, 32. pp. 57-70. ISSN 0172-780X

Holme, J. A., Gorria, M., Arlt, V. M., Ovrebo, S., Solhaug, A., Tekpli, X., Landvik, N. E., Huc, L., Fardel, O., Lagadic-Gossmann, D. (2007) Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells. CHEMICO-BIOLOGICAL INTERACTIONS, 167 (1). pp. 41-55. ISSN 0009-2797

Lord, G. M., Hollstein, M., Arlt, V. M., Roufosse, C., Pusey, C. D., Cook, T., Schmeiser, H. H. (2004) DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy. AMERICAN JOURNAL OF KIDNEY DISEASES, 43 (4). E11-E17. ISSN 0272-6386

Arlt, V. M., Frei, E., Schmeiser, H. H. (2007) ECNIS-sponsored workshop on biomarkers of exposure and cancer risk: DNA damage and DNA adduct detection and 6th GUM-32P-postlabelling workshop, German Cancer Research Center, Heidelberg, Germany, 29-30 September 2006. MUTAGENESIS, 22 (1). pp. 83-88. ISSN 0267-8357

Landvik, N. E., Gorria, M., Arlt, V. M., Asare, N., Solhaug, A., Lagadic-Gossmann, D., Holme, J. A. (2007) Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: Possible implications for their mutagenic and carcinogenic effects. TOXICOLOGY, 231 (2-3). pp. 159-174. ISSN 0300-483X

Aimová, D., Poljaková, J., Kotrbová, V., Moserová, M., Frei, E., Arlt, V. M., Stiborová, M., (2008) Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2. INTERDISCIPLINARY TOXICOLOGY, 1 (2). pp. 160-168. ISSN 1337-6853

Stiborova, M., Mares, J., Frei, E., Arlt, V. M., Martinek, V., Schmeiser, H. H. (2011) The Human Carcinogen Aristolochic Acid I Is Activated to Form DNA Adducts by Human NAD(P)H:quinone Oxidoreductase Without the Contribution of Acetyltransferases or Sulfotransferases. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 52 (6). pp. 448-459. ISSN 0893-6692

Mizerovska, J., Dracinska, H., Frei, E., Schmeiser, H. H., Arlt, V. M., Stiborova, M. (2011) Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 720 (1-2). pp. 34-41. ISSN 1383-5718

Nortier, J. L., Schmeiser, H. H., Martinez, M. C. M., Arlt, V. M., Vervaet, C., Garbar, C. H., Daelemans, P., Vanherweghem, J. L. (2003) Invasive urothelial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failure. NEPHROLOGY DIALYSIS TRANSPLANTATION, 18 (2). pp. 426-428. ISSN 0931-0509

Arlt, V. M,, Ferluga, D., Stiborova, M., Pfohl-Leszkowicz, A., Vukelic, M., Ceovic, S., Schmeiser, H. H., Cosyns, J. P. (2002) Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer? INTERNATIONAL JOURNAL OF CANCER, 101 (5). pp. 500-502. ISSN 0020-7136

Stiborova, M., Frei, E., Arlt, V. M., Schmeiser, H. H. (2008) Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 658 (1-2). pp. 55-67. ISSN 1383-5742

Arlt, V. M., Glatt, H., da Costa, G. G., Reynisson, J., Takamura-Enya, T., Phillips, D. H. (2007) Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone. TOXICOLOGICAL SCIENCES, 98 (2). pp. 445-457. ISSN 1096-6080

Mizerovská, J., Dračínská, H., Arlt, V. M., Hudeček, J., Hodek, P., Schmeiser, H. H., Frei, E. E., Stiborová, M. (2008) Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone. INTERDISCIPLINARY TOXICOLOGY, 1 (2). pp. 150-154. ISSN 1337-6853

Stiborova, M., Frei, E., Arlt, V. M., Schmeiser, H. H. (2009) THE ROLE OF BIOTRANSFORMATION ENZYMES IN THE DEVELOPMENT OF RENAL INJURY AND UROTHELIAL CANCER CAUSED BY ARISTOLOCHIC ACID: URGENT QUESTIONS AND DIFFICULT ANSWERS. BIOMEDICAL PAPERS-OLOMOUC, 153 (1). pp. 5-11. ISSN 1213-8118

Lord, G. M., Cook, T., Arlt, V. M., Schmeiser, H. H., Williams, G., Pusey, C. D. (2001) Urothelial malignant disease and chinese herbal nephropathy. LANCET, 358 (9292). pp. 1515-1516. ISSN 0140-6736

Simoes, M. L., Hockley, S. L., Schwerdtle, T., da Costa, G. G., Schmeiser, H. H., Phillips, D. H., Arlt, V. M. (2018) Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53 (vol 232, pg 86, 2008). [Correction]

Martin, F. L., Patel, I. I., Sozeri, O., Singh, P. B., Ragavan, N., Nicholson, C. M., Frei, E., Meinl, W., Glatt, H., Phillips, D. H., Arlt, V. M. (2010) Constitutive Expression of Bioactivating Enzymes in Normal Human Prostate Suggests a Capability to Activate Pro-Carcinogens to DNA-Damaging Metabolites. PROSTATE, 70 (14). pp. 1586-1599. ISSN 0270-4137

Singh, R., Arlt, V. M., Henderson, C. J., Phillips, D. H., Farmer, P. B., da Costa, G. G. (2010) Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-Phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 878 (23). pp. 2155-2162. ISSN 1570-0232

Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J., Phillips, D. H. (2011) Effect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo 4,5-b pyridine-DNA Adduct Formation in P450 Reductase Conditional Null Mice. DRUG METABOLISM AND DISPOSITION, 39 (12). pp. 2169-2173. ISSN 0090-9556

Schmeiser, H. H., Kucab, J. E., Arlt, V. M., Phillips, D. H., Hollstein, M., Gluhovschi, G., Gluhovschi, C., Modilca, M., Daminescu, L., Petrica, L., Velciov, S. (2012) Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 53 (8). pp. 636-641. ISSN 0893-6692

Bieler, C. A., Cornelius, M. G., Stiborova, M., Arlt, V. M., Wiessler, M., Phillips, D. H., Schmeiser, H. H. (2007) Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in rats. CARCINOGENESIS, 28 (5). pp. 1117-1121. ISSN 0143-3334

Hamouchene, H., Arlt, V. M., Giddings, I., Phillips, D. H. (2011) Influence of cell cycle on responses of MCF-7 cells to benzo a pyrene. BMC GENOMICS, 12. ISSN 1471-2164

Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M., Stiborova, M. (2011) Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:Cytochrome P450 Reductase Null (HRN) Mouse Model. TOXICOLOGICAL SCIENCES, 121 (1). pp. 43-56. ISSN 1096-6080

Arlt, V. M., Levova, K., Barta, F., Shi, Z. Q., Evans, J. D., Frei, E., Schmeiser, H. H., Nebert, D. W., Phillips, D. H., Stiborova, M. (2011) Role of P450 1A1 and P450 1A2 in Bioactivation versus Detoxication of the Renal Carcinogen Aristolochic Acid I: Studies in Cyp1a1(-/-), Cyp1a2(-/-), and Cyp1a1/1a2(-/-) Mice. CHEMICAL RESEARCH IN TOXICOLOGY, 24 (10). pp. 1710-1719. ISSN 0893-228X

Arlt, V. M., Phillips, D. H., Reynisson, J. (2011) Theoretical investigations on the formation of nitrobenzanthrone-DNA Adducts. ORGANIC & BIOMOLECULAR CHEMISTRY, 9 (17). pp. 6100-6110. ISSN 1477-0520

D

Chung, Y. L., Nagy, E., Zietkowski, D., Payne, G. S., Phillips, D. H., Desouza, N. M. (2013) Molecular and Metabolic Consequences Following E6 Transfection in an Isogenic Ovarian Cell Line (A2780) Pair. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 32 (5). pp. 1460-1472. ISSN 1015-8987

H

Zienolddiny, S., Skaug, V., Landvik, N. E., Ryberg, D., Phillips, D. H., Houlston, R., Haugen, A. (2009) The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. CARCINOGENESIS, 30 (8). pp. 1368-1371. ISSN 0143-3334

P

Evans, M. D., Mistry, V., Singh, R., Gackowski, D., Rozalski, R., Siomek-Gorecka, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Olinski, R., Cooke, M. S. (2016) Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2 '-deoxyguanosine. FREE RADICAL BIOLOGY AND MEDICINE, 99. pp. 385-391. ISSN 0891-5849

Beland, F. A., Churchwell, M. I., Hewer, A., Phillips, D. H., da Costa, G. G., Marques, M. M. (2004) Analysis of tamoxifen-DNA adducts in endometrial explants by MS and P-32-postlabeling. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 320 (2). pp. 297-302. ISSN 0006-291X

Tang, D. L., Phillips, D. H., Stampfer, M., Mooney, L. A., Hsu, Y. Z., Cho, S., Tsai, W. Y., Ma, J., Cole, K. J., Ni She, M., Perera, F. P. (2001) Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study. CANCER RESEARCH, 61 (18). pp. 6708-6712. ISSN 0008-5472

Perera, F. P., Mooney, L. A., Stampfer, M., Phillips, D. H., Bell, D. A., Rundle, A., Cho, S., Tsai, W. Y., Ma, J., Blackwood, A., Tang, D. L. (2002) Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study. CARCINOGENESIS, 23 (10). pp. 1641-1646. ISSN 0143-3334

Martin, F. L., Piearce, T. G., Hewer, A., Phillips, D. H., Semple, K. T. (2005) A biomarker model of sublethal genotoxicity (DNA single-strand breaks and adducts) using the sentinel organism Aporrectodea longa in spiked soil. ENVIRONMENTAL POLLUTION, 138 (2). pp. 307-315. ISSN 0269-7491

Sagredo, C., Mollerup, S., Cole, K. J., Phillips, D. H., Uppstad, H., Ovrebo, S. (2009) Biotransformation of Benzo[a]pyrene in Ahr Knockout Mice Is Dependent on Time and Route of Exposure. CHEMICAL RESEARCH IN TOXICOLOGY, 22 (3). pp. 584-591. ISSN 0893-228X

O'Donovan, M. R., Mee, C. D., Fenner, S., Teasdale, A., Phillips, D. H. (2011) Boronic acids-A novel class of bacterial mutagen. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 724 (1-2). pp. 1-6. ISSN 1383-5718

Ricceri, F., Godschalk, R. W., Peluso, M., Phillips, D. H., Agudo, A., Georgiadis, P., Loft, S., Tjonneland, A., Raaschou-Nielsen, O., Palli, D., Perera, F., Vermeulen, R., Taioli, E., Sram, R. J., Munnia, A., Rosa, F., Allione, A., Matullo, G., Vineis, P. (2010) Bulky DNA Adducts in White Blood Cells: A Pooled Analysis of 3,600 Subjects. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 19 (12). pp. 3174-3181. ISSN 1055-9965

Telli-Karakoc, F., Ruddock, P., Bird, D., Hewer, A., Van Schanke, A., Phillips, D. H., Peters, L. D. (2002) Correlative changes in metabolism and DNA damage in turbot (Scophthalmus maximus) exposed to benzo[a]pyrene. MARINE ENVIRONMENTAL RESEARCH, 54 (3-5). pp. 511-515. ISSN 0141-1136

Telli-Karakoc, F., Gaines, A. F., Hewer, A., Phillips, D. (2001) Differences between blood and liver aromatic DNA adduct formation. ENVIRONMENT INTERNATIONAL, 26 (3). pp. 143-148. ISSN 0160-4120

Veglia, F., Loft, S., Matullo, G., Peluso, M., Munnia, A., Perera, F., Phillips, D. H., Tang, D., Autrup, H., Raaschou-Nielsen, O., Tjonneland, A., Vineis, P., Genair EPIC Invest, [Group Author] (2008) DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis. CARCINOGENESIS, 29 (5). pp. 932-936. ISSN 0143-3334

Phillips, D. H. (2005) DNA adducts as markers of exposure and fisk. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 577 (1-2). pp. 284-292. ISSN 0027-5107

Johansson, C., Moller, P., Forchhammer, L., Loft, S., Godschalk, R. W. L., Langie, S. A. S., Lumeij, S., Jones, G. D. D., Kwok, R. W. L., Azqueta, A., Phillips, D. H., Sozeri, O., Routledge, M. N., Charlton, A. J., Riso, P., Porrini, M., Allione, A., Matullo, G., Palus, J., Stepnik, M., Collins, A. R., Moller, L. (2010) An ECVAG dagger trial on assessment of oxidative damage to DNA measured by the comet assay. MUTAGENESIS, 25 (2). pp. 125-132. ISSN 0267-8357

Beland, F. A., Churchwell, M. I., Doerge, D. R., Parkin, D. R., Malejka-Giganti, D., Hewer, A., Phillips, D. H., Carmichael, P. L., da Costa, G. G., Marques, M. M. (2004) Electrospray ionization-tandem mass spectrometry and P-32-postlabeling analyses of tamoxifen-DNA adducts in humans. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 96 (14). pp. 1099-1104. ISSN 0027-8874

Martins, C., Cacao, R., Cole, K. J., Phillips, D. H., Laires, A., Rueff, J., Rodrigues, A. S. (2012) Estragole: A weak direct-acting food-borne genotoxin and potential carcinogen. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 747 (1). pp. 86-92. ISSN 1383-5718

Phillips DH. (2002) The formation of DNA adducts. In: The Cancer Handbook. MacMillan, London, UK, pp. 293-306.

Kirsch-Volders, M., Bonassi, S., Herceg, Z., Hirvonen, A., Moller, L., Phillips, D. H. (2010) Gender-related differences in response to mutagens and carcinogens. MUTAGENESIS, 25 (3). pp. 213-221. ISSN 0267-8357

Jones, C. J., Phillips, D. H. (2005) The genome stability network. MUTAGENESIS, 20 (3). p. 151. ISSN 0267-8357

Martin, F. L., Cole, K. J., Weaver, G., Hong, G. S., Lam, B. C., Balaram, P., Grover, P. L., Phillips, D. H. (2001) Genotoxicity of human breast milk from different countries. MUTAGENESIS, 16 (5). pp. 401-406. ISSN 0267-8357

Jiao, H. Y., Allinson, S. L., Walsh, M. J., Hewitt, R., Cole, K. J., Phillips, D. H., Martin, F. L. (2007) Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation. MUTAGENESIS, 22 (2). pp. 111-116. ISSN 0267-8357

Peters, L. D., Telli-Karakoc, F., Hewer, A., Phillips, D. H. (2002) In vitro mechanistic differences in benzo[a]pyrene-DNA adduct formation using fish liver and mussel digestive gland microsomal activating systems. MARINE ENVIRONMENTAL RESEARCH, 54 (3-5). pp. 499-503. ISSN 0141-1136

Kalantzi, O. I., Hewitt, R., Ford, K. J., Alcock, R. E., Thomas, G. O., Morris, J. A., Hewer, A., Phillips, D. H., Jones, K. C., Martin, F. L. (2004) Inter-individual differences in the ability of human milk-fat extracts to enhance the genotoxic potential of the procarcinogen benzo[a]pyrene in MCF-7 breast cells. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 38 (13). pp. 3614-3622. ISSN 0013-936X

Hockley, S. L., Mathijs, K., Staal, Y. C. M., Brewer, D., Giddings, I., van Delft, J. H. M., Phillips, D. H. (2009) Interlaboratory and Interplatform Comparison of Microarray Gene Expression Analysis of HepG2 Cells Exposed to Benzo(a)pyrene. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 13 (2). pp. 115-125. ISSN 1536-2310

Lind, H., Zienolddiny, S., Ryberg, D., Skaug, V., Phillips, D. H., Haugen, A. (2005) Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: A possible interaction with polymorphisms in the interleukin 1 beta gene. LUNG CANCER, 50 (3). pp. 285-290. ISSN 0169-5002

Phillips, D. H. (2005) Macromolecular adducts as biomarkers of human exposure to polycyclic aromatic hydrocarbons. In: The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons. Imperial College Press, London, pp. 137-169. ISBN 978-186094417-8

Phillips DH. (2001) Mechanisms of liver carcinogenesis by antiestrogens. In: Hormone Therapy in Breast and Prostate Cancer. Cancer Drug Discovery and Development . Humana Press, Totowa, USA, pp. 69-81. ISBN 978-089603673-4

Pfau, W., Martin, F. L., Cole, K. J., Weaver, G., Marquardt, H., Phillips, D. H., Grover, P. L. (2001) Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 498 (1-2). pp. 207-217. ISSN 1383-5718

Zienolddiny, S., Ryberg, D., Svendsrud, D. H., Eilertsen, E., Skaug, V., Hewer, A., Phillips, D. H., Riele, H. T., Haugen, A. (2006) Msh2 deficiency increases susceptibility to benzo[a]pyrene-induced lymphomagenesis. INTERNATIONAL JOURNAL OF CANCER, 118 (11). pp. 2899-2902. ISSN 0020-7136

Hussain, S. P., Amstad, P., Raja, K., Sawyer, M., Hofseth, L., Shields, P. G., Hewer, A., Philips, D. H., Ryberg, D., Haugen, A., Harris, C. C. (2001) Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung. CANCER RESEARCH, 61 (17). pp. 6350-6355. ISSN 0008-5472

Eastmond, D. A., Hartwig, A., Anderson, D., Anwar, W. A., Cimino, M. C., Dobrev, I., Douglas, G. R., Nohmi, T., Phillips, D. H., Vickers, C. (2009) Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme. MUTAGENESIS, 24 (4). pp. 341-349. ISSN 0267-8357

Phillips, D. H., Martin, F. L., Williams, J. A., Wheat, L. M. C., Nolan, L., Cole, K. J., Grover, P. L. (2002) Mutagens in human breast lipid and milk: The search for environmental agents that initiate breast cancer. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 39 (2-3). pp. 143-149. ISSN 0893-6692

Al-Buheissi, S. Z., Patel, H. R., Meinl, W., Hewer, A., Bryan, R. L., Glatt, H., Miller, R. A., Phillips, D. H. (2006) N-acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation. PHARMACOGENETICS AND GENOMICS, 16 (6). pp. 391-399. ISSN 1744-6872

Williams, J. A., Stone, E. M., Fakis, G., Johnson, N., Cordell, J. A., Meinl, W., Glatt, H., Sim, E., Phillips, D. H. (2001) N-acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. PHARMACOGENETICS, 11 (5). pp. 373-388. ISSN 0960-314X

Phillips, D. H., Jenkinson, P. (2005) p53 tumour suppressor gene and the tobacco industry. LANCET, 365 (9464). pp. 1026-1027. ISSN 0140-6736

Bhana, S., Hewer, A., Phillips, D. H., Lloyd, D. R. (2008) p53-dependent global nucleotide excision repair of cisplatin-induced intrastrand cross links in human cells. MUTAGENESIS, 23 (2). pp. 131-136. ISSN 0267-8357

Pratt, M. M., John, K., MacLean, A. B., Afework, S., Phillips, D. H., Poirier, M. C. (2011) Polycyclic Aromatic Hydrocarbon (PAH) Exposure and DNA Adduct Semi-Quantitation in Archived Human Tissues. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 8 (7). pp. 2675-2691. ISSN 1660-4601

Perera, F. P., Wang, S., Vishnevetsky, J., Zhang, B. Z., Cole, K. J., Tang, D. L., Rauh, V., Phillips, D. H. (2011) Polycyclic Aromatic Hydrocarbons-Aromatic DNA Adducts in Cord Blood and Behavior Scores in New York City Children. ENVIRONMENTAL HEALTH PERSPECTIVES, 119 (8). pp. 1176-1181. ISSN 0091-6765

Zienolddiny, S., Campa, D., Lind, H., Ryberg, D., Skaug, V., Stangeland, L., Phillips, D. H., Canzian, F., Haugen, A. (2006) Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. CARCINOGENESIS, 27 (3). pp. 560-567. ISSN 0143-3334

Martin, F. L., Cole, K. J,. Muir, G. H., Kooiman, G. G., Williams, J. A., Sherwood, R. A., Grover, P. L., Phillips, D. H. (2002) Primary cultures of prostate cells and their ability to activate carcinogens. PROSTATE CANCER AND PROSTATIC DISEASES, 5 (2). pp. 96-104. ISSN 1365-7852

Martin, F. L., Cole, K. J., Phillips, D. H., Grover, P. L. (2002) The proteolytic release of genotoxins from cooked beef. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 293 (5). pp. 1497-1501. ISSN 0006-291X

Singh, M. N., Stringfellow, H. F., Walsh, M. J., Ashton, K. M., Paraskevaidis, E., Abdo, K. R., Martin-Hirsch, P. L., Phillips, D. H., Martin, F. L. (2008) Quantifiable mRNA transcripts for tamoxifen-metabolising enzymes in human endometrium. TOXICOLOGY, 249 (1). pp. 85-90. ISSN 0300-483X

John, K., Ragavan, N., Pratt, M. M., Singh, P. B., Al-Buheissi, S., Matanhelia, S. S., Phillips, D. H., Poirier, M. C., Martin, F. L. (2009) Quantification of Phase I/II Metabolizing Enzyme Gene Expression and Polycyclic Aromatic Hydrocarbon-DNA Adduct Levels in Human Prostate. PROSTATE, 69 (5). pp. 505-519. ISSN 0270-4137

Berge, G., Ovrebo, S., Botnen, I. V., Hewer, A., Phillips, D. H., Haugen, A., Mollerup, S. (2004) Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells. BRITISH JOURNAL OF CANCER, 91 (2). pp. 333-338. ISSN 0007-0920

Berge, G., Mollerup, S., Ovrebo, S., Hewer, A., Phillips, D. H., Eilertsen, E., Haugen, A. (2004) Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung. LUNG CANCER, 45 (3). pp. 289-297. ISSN 0169-5002

Mollerup, S., Berge, G., Baera, R., Skaug, V., Hewer, A., Phillips, D. H., Strangeland, L., Haugen, A. (2006) Sex differences in risk of lung cancer: expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts. INTERNATIONAL JOURNAL OF CANCER, 119 (4). pp. 741-744. ISSN 0020-7136

Uppstad, H., Osnes, G. H., Cole, K. J., Phillips, D. H., Haugen, A., Mollerup, S. (2011) Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells. LUNG CANCER, 71 (3). pp. 264-270. ISSN 0169-5002

Phillips, D. H., Garte, S. (2008) Smoking and breast cancer: Is there really a link? CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 17 (1). pp. 1-2. ISSN 1055-9965

Phillips, D. H., Hewer, A., Scholefield, J. H., Skinner, P. (2004) Smoking-related DNA adducts in anal epithelium. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 560 (2). pp. 167-172. ISSN 1383-5718

Phillips, D. H. (2002) Smoking-related DNA and protein adducts in human tissues. CARCINOGENESIS, 23 (12). pp. 1979-2004. ISSN 0143-3334

Thybaud, V., MacGregor, J. T., Muller, L., Crebelli, R., Dearfield, K., Douglas, G., Farmer, P. B., Gocke, E., Hayashi, M., Lovell, D. P., Lutz, W. K., Marzin, D., Moore, M., Nohmi, T., Phillips, D. H., Van Benthem, J. (2011) Strategies in case of positive in vivo results in genotoxicity testing. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 723 (2). pp. 121-128. ISSN 1383-5718

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Ioannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2012) STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement. MUTAGENESIS, 27 (1). pp. 17-29. ISSN 0267-8357

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Loannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2011) STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement. PREVENTIVE MEDICINE, 53 (6). pp. 377-387. ISSN 0091-7435

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Ioannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2012) STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 42 (1). pp. 1-16. ISSN 0014-2972

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Ioannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2012) STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement (vol 53, pg 377, 2011). [Correction]

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Ioannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2011) STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology STROBE-ME: an extension of the STROBE statement. JOURNAL OF CLINICAL EPIDEMIOLOGY, 64 (12). pp. 1350-1363. ISSN 0895-4356

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Ioannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2011) STrengthening the Reporting of OBservational studies in Epidemiology-Molecular Epidemiology (STROBE-ME): An Extension of the STROBE Statement. PLOS MEDICINE, 8 (10). ISSN 1549-1277

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Ioannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2011) STrengthening the reporting of OBservational studies in Epidemiology-Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 26 (10). pp. 797-810. ISSN 0393-2990

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Ioannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2012) STrengthening the reporting of OBservational studies in Epidemiology-Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement (vol 26, pg 797, 2011). [Correction]

Gallo, V., Egger, M., McCormack, V., Farmer, P. B., Ioannidis, J. P. A., Kirsch-Volders, M., Matullo, G., Phillips, D. H., Schoket, B., Stromberg, U., Vermeulen, R., Wild, C., Porta, M., Vineis, P. (2012) STrengthening the Reporting of OBservational studies in Epidemiology: Molecular Epidemiology STROBE-ME. An extension of the STROBE statement. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 66 (9). pp. 844-854. ISSN 0143-005X

Beland, F. A., Marques, M. M., da Costa, G. G., Phillips, D. H. (2005) Tamoxifen - DNA adduct formation in human endometrium. CHEMICAL RESEARCH IN TOXICOLOGY, 18 (10). pp. 1507-1509. ISSN 0893-228X

Phillips, D. H., Martin, F. L., Grover, P. L., Williams, J. A. (2001) Toxicological basis for a possible association of breast cancer with smoking and other environmental carcinogens. JOURNAL OF WOMEN'S CANCER, 3. pp. 17-22.

Arnott, C. H., Scott, K. A., Moore, R. J., Hewer, A., Phillips, D. H., Parker, P., Balkwill, F. R., Owens, D. M. (2002) Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway. ONCOGENE, 21 (31). pp. 4728-4738. ISSN 0950-9232

Phillips, D. H. (2001) Understanding the genotoxicity of tamoxifen? CARCINOGENESIS, 22 (6). pp. 839-849. ISSN 0143-3334

Gallo, V., Khan, A., Gonzales, C., Phillips, D. H., Schoket, B., Gyorffy, E., Anna, L., Kovacs, K., Moller, P., Loft, S., Kyrtopoulos, S., Matullo, G., Vineis, P. (2008) Validation of biomarkers for the study of environmental carcinogens: a review. BIOMARKERS, 13 (5). pp. 505-534. ISSN 1354-750X

Forchhammer, L., Johansson, C., Loft, S., Moller, L., Godschalk, R. W. L., Langie, S. A. S., Jones, G. D. D., Kwok, R. W. L., Collins, A. R., Azqueta, A., Phillips, D. H., Sozeri, O., Stepnik, M., Palus, J., Vogel, U., Wallin, H., Routledge, M. N., Handforth, C., Allione, A., Matullo, G., Teixeira, J. P., Costa, S., Riso, P., Porrini, M., Moller, P. (2010) Variation in the measurement of DNA damage by comet assay measured by the ECVAG dagger inter-laboratory validation trial. MUTAGENESIS, 25 (2). pp. 113-123. ISSN 0267-8357

Morabia, A., Ambrosone, C. B., Baron, J. A., Phillips, D. H., Russo, I. H. (2001) What do we currently know about the epidemiological and biological plausibility of the association of smoking and breast cancer? JOURNAL OF WOMEN'S CANCER, 3. pp. 5-8.

Stiborova, M., Dracinska, H., Martinkova, M., Mizerovska, J., Hudecek, J., Hodek, P., Liberda, J., Frei, E., Schmeiser, H. H., Phillips, D. H., Arlt, V. M. (2009) 3-Aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 676 (1-2). pp. 93-101. ISSN 1383-5718

Arlt, V. M., Hewer, A., Sorg, B. L., Schmeiser, H. H., Phillips, D. H., Stiborova, M. (2004) 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2. CHEMICAL RESEARCH IN TOXICOLOGY, 17 (8). pp. 1092-1101. ISSN 0893-228X

Phillips, D. H., Hewer, A., Arlt, V. M. (2005) 32P-postlabeling analysis of DNA adducts. METHODS IN MOLECULAR BIOLOGY, 291. pp. 3-12. ISSN 1064-3745

Arlt, V. M., Glatt, H., Muckel, E,, Pabel, U., Sorg, B. L., Seidel, A., Frank, H., Schmeiser, H. H., Phillips, D. H. (2003) Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells. INTERNATIONAL JOURNAL OF CANCER, 105 (5). pp. 583-592. ISSN 0020-7136

Arlt, V. M., Cole, K. J., Phillips, D. H. (2004) Activation of 3-nitrobenzanthrone and its metabolites to DNA-damaging species in human B lymphoblastoid MCL-5 cells. MUTAGENESIS, 19 (2). pp. 149-156. ISSN 0267-8357

Arlt, V. M., Stiborova, M., vom Brocke, J., Simoes, M. L., Lord, G. M., Nortier, J. L., Hollstein, M., Phillips, D. H., Schmeiser, H. H. (2007) Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer. CARCINOGENESIS, 28 (11). pp. 2253-2261. ISSN 0143-3334

Gillerot, G., Goffin, E., Moulin, P., Arlt, V. M., Phillips, D. H., Cosyns, J. P., Devuyst, O. (2003) Aristolochic acid nephropathy and the peritoneum: Functional, structural, and molecular studies. KIDNEY INTERNATIONAL, 64 (5). pp. 1883-1892. ISSN 0085-2538

Arlt, V. M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Stiborova, M. (2006) Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases. CANCER LETTERS, 234 (2). pp. 220-231. ISSN 0304-3835

Stiborova, M., Levova, K., Barta, F., Shi, Z. Q., Frei, E., Schmeiser, H. H., Nebert, D. W., Phillips, D. H., Arlt, V. M. (2012) Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2. TOXICOLOGICAL SCIENCES, 125 (2). pp. 345-358. ISSN 1096-6080

Lo, S. H., Wong, K. S., Arlt, V. M., Phillips, D. H., Lai, C. K., Poon, W. T., Chan, C. K., Mo, K. L., Chan, K. W., Chan, A. (2005) Detection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathy. AMERICAN JOURNAL OF KIDNEY DISEASES, 45 (2). pp. 407-410. ISSN 0272-6386

Ovrevik, J., Arlt, V. M., Oya, E., Nagy, E., Mollerup, S., Phillips, D. H., Lag, M., Holme, J. A. (2010) Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells. TOXICOLOGY AND APPLIED PHARMACOLOGY, 242 (3). pp. 270-280. ISSN 0041-008X

Mei, N., Arlt, V. M., Phillips, D. H., Heflich, R. H., Chen, T. (2006) DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 602 (1—2). pp. 83-91. ISSN 0027-5107

Bieler, C. A., Cornelius, M. G., Klein, R., Arlt, V. M., Wiessler, M., Phillips, D. H., Schmeiser, H. H. (2005) DNA adduct formation by the environmental contaminant 3-Nitrobenzanthrone after intratracheal instillation in rats. INTERNATIONAL JOURNAL OF CANCER, 116 (6). pp. 833-838. ISSN 0020-7136

Arlt, V. M., Sorg, B. L., Osborne, M., Hewer, A., Seidel, A., Schmeiser, H. H., Phillips, D. H. (2003) DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 300 (1). pp. 107-114. ISSN 0006-291X

Kanno, T., Kawanishi, M., Takamura-Enya, T., Arlt, V. M., Phillips, D. H., Yagi, T. (2007) DNA adduct formation in human hepatoma cells treated with 3-nitrobenzanthrone: analysis by the P-32-postlabeling method. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 634 (1-2). pp. 184-191. ISSN 1383-5718

Arlt, V. M., Zhan, L., Schmeiser, H. H., Honma, M., Hayashi, M., Phillips, D. H., Suzuki, T. (2004) DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 43 (3). pp. 186-195. ISSN 0893-6692

Oya, E., Ovrevik, J., Arlt, V. M., Nagy, E., Phillips, D. H., Holme, J. A. (2011) DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis. MUTAGENESIS, 26 (6). pp. 697-708. ISSN 0267-8357

Lebeau, C., Debelle, F. D., Arlt, V. M., Pozdzik, A., De Prez, E. G., Phillips, D. H., Deschodt-Lanckman, M. M., Vanherweghem, J. L., Nortier, J. L. (2005) Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies. NEPHROLOGY DIALYSIS TRANSPLANTATION, 20 (11). pp. 2321-2332. ISSN 0931-0509

Debelle, F., Nortier, J., Arlt, V. M., De Prez, E., Vienne, A., Salmon, I., Phillips, D. H., Deschodt-Lanckman, M., Vanherweghem, J. L. (2003) Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy. ARCHIVES OF TOXICOLOGY, 77 (4). pp. 218-226. ISSN 0340-5761

Stiborova, M., Dracinska, H., Hajkova, J., Kaderabkova, P., Frei, E., Schmeiser, H. H., Soucek, P., Phillips, D. H., Arlt, V. M. (2006) The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and-1A2 and NAD(P) H : quinone oxidoreductase. DRUG METABOLISM AND DISPOSITION, 34 (8). pp. 1398-1405. ISSN 0090-9556

Stiborova, M., Dracinska, H., Mizerovska, J., Frei, E., Schmeiser, H. H., Hudecek, J., Hodek, P., Phillips, D. H., Arlt, V. M. (2008) The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H : quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity. TOXICOLOGY, 247 (1). pp. 11-22. ISSN 0300-483X

Arlt, V. M., Zuo, J., Trenz, K., Roufosse, C. A., Lord, G. M., Nortier, J. L., Schmeiser, H. H., Hollstein, M., Phillips, D. H. (2011) Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice. INTERNATIONAL JOURNAL OF CANCER, 128 (1). pp. 21-32. ISSN 0020-7136

Simoes, M. L., Hockley, S. L., Schwerdtle, T., da Costa, G. G., Schmeiser, H. H., Phillips, D. H., Arlt, V. M. (2008) Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53. TOXICOLOGY AND APPLIED PHARMACOLOGY, 232 (1). pp. 86-98. ISSN 0041-008X

Schmeiser, H. H., Fuerstenberger, G., Takamura-Enya, T., Phillips, D. H., Arlt, V. M. (2009) The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin. CANCER LETTERS, 284 (1). pp. 21-29. ISSN 0304-3835

Arlt, V. M., Gingerich, J., Schmeiser, H. H., Phillips, D. H., Douglas, G. R., White, P. A. (2008) Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in Muta (TM) Mouse and lung epithelial cells derived from Muta (TM) Mouse. MUTAGENESIS, 23 (6). pp. 483-490. ISSN 0267-8357

Phillips, D. H., Arlt, V. M. (2009) Genotoxicity: damage to DNA and its consequences. EXS, 99. pp. 87-110. ISSN 1023-294X

Arlt, V. M., Stiborova, M., Hewer, A., Schmeiser, H. H., Phillips, D. H. (2003) Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: Evidence for reductive activation by human NADPH : cytochrome P450 reductase. CANCER RESEARCH, 63 (11). pp. 2752-2761. ISSN 0008-5472

Hockley, S. L., Arlt, V. M., Jahnke, G., Hartwig, A., Giddings, I., Phillips, D. H. (2008) Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. CARCINOGENESIS, 29 (1). pp. 202-210. ISSN 0143-3334

Courter, L. A., Luch, A., Musafia-Jeknic, T., Arlt, V. M., Fischer, K., Bildfell, R., Pereira, C., Phillips, D. H., Poirier, M. C., Baird, W. M. (2008) The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo. CANCER LETTERS, 265 (1). pp. 135-147. ISSN 0304-3835

Kucab, J. E., Phillips, D. H., Arlt, V. M. (2010) Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model. FEBS JOURNAL, 277 (12). pp. 2567-2583. ISSN 1742-464X

Stiborova, M., Martinek, V., Svobodova, M., Sistkova, J., Dvorak, Z., Ulrichova, J., Simanek, V., Frei, E., Schmeiser, H. H., Phillips, D. H., Arlt, V. M. (2010) Mechanisms of the Different DNA Adduct Forming Potentials of the Urban Air Pollutants 2-Nitrobenzanthrone and Carcinogenic 3-Nitrobenzanthrone. CHEMICAL RESEARCH IN TOXICOLOGY, 23 (7). pp. 1192-1201. ISSN 0893-228X

Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R., Phillips, D. H. (2008) Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice. CARCINOGENESIS, 29 (3). pp. 656-665. ISSN 0143-3334

Kucab, J. E., Phillips, D. H., Arlt, V. M. (2012) Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 53 (3). pp. 207-217. ISSN 0893-6692

Arlt, V. M., Glatt, H., Muckel, E., Pabel, U., Sorg, B. L., Schmeiser, H. H., Phillips, D. H. (2002) Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase. CARCINOGENESIS, 23 (11). pp. 1937-1945. ISSN 0143-3334

Bakhiya, N., Arlt, V. M., Bahn, A., Burckhardt, G., Phillips, D. H., Glatt, H. (2009) Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. TOXICOLOGY, 264 (1-2). pp. 74-79. ISSN 0300-483X

Stiborova, M., Arlt, V. M., Henderson, C. J., Roland Wolf, C., Frei, E., Schmeiser, H. H., Phillips, D. H. (2005) Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone. BIOMED PAP MED FAC UNIV PALACKY OLOMOUC CZECH REPUB, 149 (2). pp. 191-197. ISSN 1213-8118

Reynisson, J., Stiborova, M., Martinek, V., do Costa, G. G., Phillips, D. H., Arlt, V. M. (2008) Mutagenic Potential of Nitrenium Ions of Nitrobenzanthrones: Correlation Between Theory and Experiment. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 49 (8). pp. 659-667. ISSN 0893-6692

Phillips, D. H., Arlt, V. M. (2007) The P-32-postlabeling assay for DNA adducts. NATURE PROTOCOLS, 2 (11). pp. 2772-2781. ISSN 1745-2473

da Costa, G. G., Singh, R., Arlt, V. M., Mirza, A., Richards, M., Takamura-Enya, T., Schmeiser, H. H., Farmer, P. B., Phillips, D. H. (2009) Quantification of 3-Nitrobenzanthrone-DNA Adducts Using Online Column-Switching HPLC-Electrospray Tandem Mass Spectrometry. CHEMICAL RESEARCH IN TOXICOLOGY, 22 (11). pp. 1860-1868. ISSN 0893-228X

Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H., Frei, E. (2008) Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse. TOXICOLOGY AND APPLIED PHARMACOLOGY, 226 (3). pp. 318-327. ISSN 0041-008X

Lemieux, C. L., Douglas, G. R., Gingerich, J., Phonethepswath, S., Dertinger, S. D., Phillips, D. H., Arlt, V. M., White, P. A. (2011) Simultaneous Measurement of Benzo a pyrene-induced Pig-a and lacZ Mutations, Micronuclei and DNA Adducts in Muta (TM) Mouse. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 52 (9). pp. 756-765. ISSN 0893-6692

Hockley, S. L., Arlt, V. M., Brewer, D., Giddings, I., Phillips, D. H. (2006) Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2. BMC GENOMICS, 7. ISSN 1471-2164

Nedelko, T., Arlt, V. N., Phillips, D. H., Hollstein, M. (2009) TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours. INTERNATIONAL JOURNAL OF CANCER, 124 (4). pp. 987-990. ISSN 0020-7136

Kim, S. I., Arlt, V. M., Yoon, J. I., Cole, K. J., Pfeifer, G. P., Phillips, D. H., Besaratinia, A. (2011) Whole body exposure of mice to secondhand smoke induces dose-dependent and persistent promutagenic DNA adducts in the lung. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 716 (1-2). pp. 92-98. ISSN 0027-5107

Al-Buheissi, S. Z., Cole, K. J., Hewer, A., Kumar, V., Bryan, R. L., Hudson, D. L., Patel, H. R., Nathan, S., Miller, R. A., Phillips, D. H. (2006) The expression of xenobiotic-metabolizing enzymes in human prostate and in prostate epithelial cells (PECs) derived from primary cultures. PROSTATE, 66 (8). pp. 876-885. ISSN 0270-4137

Moriwaki, H., Osborne, M. R., Phillips, D. H. (2008) Effects of mixing metal ions on oxidative DNA damage mediated by a Fenton-type reduction. TOXICOLOGY IN VITRO, 22 (1). pp. 36-44. ISSN 0887-2333

Schild, L. J., Phillips, D. H., Osborne, M. R., Hewer, A., Beland, F. A., Churchwell, M. I., Brown, K., Gaskell, M., Wright, E., Poirier, M. C. (2005) Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods. MUTAGENESIS, 20 (2). pp. 115-124. ISSN 0267-8357

Donnelly, E. T., Bardwell, H., Thomas, G. A., Williams, E. D., Hoper, M., Crowe, P., McCluggage, W. G., Stevenson, M., Phillips, D. H., Hewer, A., Osborne, M. R., Campbell, F. C. (2005) Metallothionein crypt-restricted immunopositivity indices (MTCRII) correlate with aberrant crypt foci (ACF) in mouse colon. BRITISH JOURNAL OF CANCER, 92 (12). pp. 2160-2165. ISSN 0007-0920

Donnelly, E. T., Bardwell, H., Thomas, G. A., Williams, E. D., Hoper, M., Crowe, P., McCluggage, W. G., Stevenson, M., Phillips, D. H., Hewer, A., Osborne, M. R., Campbell, F. C. (2004) Modulation of N-methyl-N-nitrosourea-induced crypt restricted metallothionein immunopositivity in mouse colon by a non-genotoxic diet-related chemical. CARCINOGENESIS, 25 (5). pp. 847-855. ISSN 0143-3334

Jorge, S. A. C., Menck, C. F. M., Sies, H., Osborne, M. R., Phillips, D. H., Sarasin, A., Stary, A. (2002) Mutagenic fingerprint of ozone in human cells. DNA REPAIR, 1 (5). pp. 369-378. ISSN 1568-7864

Osborne, M. R., Hewer, A., Phillips, D. H. (2001) Resolution of a-hydroxytamoxifen: R-isomer forms more DNA adducts in rat liver cells. CHEMICAL RESEARCH IN TOXICOLOGY, 14 (7). pp. 888-893. ISSN 0893-228X

Osborne, M. R., Hewer, A., Phillips, D. H. (2004) Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: The R-isomer forms more DNA adducts in rat liver cells. CHEMICAL RESEARCH IN TOXICOLOGY, 17 (5). pp. 697-701. ISSN 0893-228X

Arlt, V. M., Stiborova, M., Henderson, C. J., Osborne, M. R., Bieler, C. A., Frei, E., Martinek, V., Sopko, B., Wolf, C. R., Schmeiser, H. H., Phillips, D. H. (2005) Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H : quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols. CANCER RESEARCH, 65 (7). pp. 2644-2652. ISSN 0008-5472

Arlt, V. M., Schmeiser, H. H., Osborne, M. R., Kawanishi, M., Kanno, T., Yagi, T., Phillips, D. H., Takamura-Enya, T. (2006) Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N-2 position of guanine and at the N-6 position of adenine. INTERNATIONAL JOURNAL OF CANCER, 118 (9). pp. 2139-2146. ISSN 0020-7136

Phillips, D. H., Hewer, A., Osborne, M. R., Cole, K. J., Churchill, C., Arlt, V. M. (2005) Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment. MUTAGENESIS, 20 (4). pp. 297-303. ISSN 0267-8357

Osborne, M. R., Arlt, V. M., Kliem, C., Hull, W. E., Mirza, A., Bieler, C. A., Schmeiser, H. H., Phillips, D. H. (2005) Synthesis, characterization, and P-32-postlabeling analysis of DNA adducts derived from the environmental contaminant 3-Nitrobenzanthrone. CHEMICAL RESEARCH IN TOXICOLOGY, 18 (6). pp. 1056-1070. ISSN 0893-228X

W

Hockley, S. L., Arlt, V. M., Brewer, D., te Poele, R., Workman, P., Giddings, I., Phillips, D. H. (2007) AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. CHEMICAL RESEARCH IN TOXICOLOGY, 20 (12). pp. 1797-1810. ISSN 0893-228X

This list was generated on Tue Feb 19 20:52:13 2019 UTC.
The Royal Marsden - NHS foundation trust