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Tanaka, N., Tani, Y., Tada, T., Lee, Y. F., Kanaori, K., Kunugi, S. (2006) The roles of conserved amino acids on substrate binding and conformational integrity of ClpB N-terminal domain. BIOCHEMISTRY, 45 (28). pp. 8556-8561. ISSN 0006-2960

Bunney, T. D., Harris, R., Gandarillas, N. L., Josephs, M. B., Roe, S. M., Sorli, S. C., Paterson, H. F., Rodrigues-Lima, F., Esposito, D., Ponting, C. P., Gierschik, P., Pearl, L. H., Driscoll, P. C., Katan, M. (2006) Structural and mechanistic insights into ras association domains of phospholipase C epsilon. MOLECULAR CELL, 21 (4). pp. 495-507. ISSN 1097-2765

Dore, A. S., Kilkenny, M. L., Jones, S. A., Oliver, A. W., Roe, S. M., Bell, S. D., Pearl, L. H. (2006) Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. NUCLEIC ACIDS RESEARCH, 34 (16). pp. 4515-4526. ISSN 0305-1048

Vaughan, C. K., Gohlke, U., Sobott, F., Good, V. M., Ali, M. M. U., Prodromou, C., Robinson, C. V., Saibil, H. R., Pearl, L. H. (2006) Structure of an Hsp90-Cdc37-Cdk4 complex. MOLECULAR CELL, 23 (5). pp. 697-707. ISSN 1097-2765

Spagnolo, L., Rivera-Calzada, A., Pearl, L. H., Llorca, O. (2006) Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. MOLECULAR CELL, 22 (4). pp. 511-519. ISSN 1097-2765

Oliver, A. W., Paul, A., Boxall, K. J., Barrie, S. E., Aherne, G. W., Garrett, M. D., Mittnacht, S., Pearl, L. H. (2006) Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. EMBO JOURNAL, 25 (13). pp. 3179-3190. ISSN 0261-4189

Kumar, S., Nagl, S., Kalsi, J. K., Ravirajan, C. T., Athwal, D., Latchman, D. S., Pearl, L. H., Isenberg, D. A. (2005) Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody. MOLECULAR IMMUNOLOGY, 42 (1). pp. 39-48. ISSN 0161-5890

Zhang MH, Windheim M, Roe SM, Peggie M, Cohen P, Prodromou C, Pearl LH (2005) Chaperoned ubiquitylation - Crystal structures of the CHIPU box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. MOLECULAR CELL, 20 (4). pp. 525-538. ISSN 1097-2765

Passmore, L. A., Barford, D. (2005) Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. EMBO REPORTS, 6 (9). pp. 873-878. ISSN 1469-221X

Li SQ, Depetris RS, Barford D, Chernoff J, Hubbard SR (2005) Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. STRUCTURE, 13 (11). pp. 1643-1651. ISSN 0969-2126

Oliver, A. W., Jones, S. A., Roe, S. M., Matthews, S., Goodwin, G. H., Pearl, L. H. (2005) Crystal structure of the proximal BAH domain of the polybromo protein. BIOCHEMICAL JOURNAL, 389 (Part 3). pp. 657-664. ISSN 0264-6021

Groen, A., Lemeer, S., van der Wijk, T., Overvoorde, J., Heck, A. J. R., Ostman, A., Barford, D., Slijper, M., den Hertog, J. (2005) Differential oxidation of protein-tyrosine phosphatases. JOURNAL OF BIOLOGICAL CHEMISTRY, 280 (11). pp. 10298-10304. ISSN 0021-9258

Cheung KMJ, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 15 (14). pp. 3338-3343. ISSN 0960-894X

Kumar, S., Bunting, K. A., Kalsi, J., Hinks, J. A., Latchman, D. S., Pearl, L. H., Isenberg, D. A. (2005) Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV. IMMUNOLOGY, 114 (3). pp. 418-427. ISSN 0019-2805

Yang, J., Roe, S. M., Cliff, M. J., Williams, M. A., Ladbury, J. E., Cohen, P. T. W., Barford, D. (2005) Molecular basis for TPR domain-mediated regulation of protein phosphatase. EMBO JOURNAL, 24 (1). pp. 1-10. ISSN 0261-4189

Cliff MJ, Williams MA, Brooke-Smith J, Barford D, Ladbury JE (2005) Molecular recognition via coupled folding and binding in a TPR domain. JOURNAL OF MOLECULAR BIOLOGY, 346 (3). pp. 717-732. ISSN 0022-2836

Hu B, Liao CY, Millson SH, Mollapour M, Prodromou C, Pearl LH, Piper PW, Panaretou B (2005) Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. MOLECULAR MICROBIOLOGY, 55 (6). pp. 1735-1750. ISSN 0950-382X

Passmore, L. A., Booth, C. R., Venien-Bryan, C., Ludtke, S. J., Fioretto, C., Johnson, L. N., Chiu, W., Barford, D. (2005) Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. MOLECULAR CELL, 20 (6). pp. 855-866. ISSN 1097-2765

Parker, J. S., Roe, S. M., Barford, D. (2005) Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. NATURE, 434 (7033). pp. 663-666. ISSN 0028-0836

Rivera-Calzada A, Maman JP, Spagno L, Pearl LH, Llorca O (2005) Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). STRUCTURE, 13 (2). pp. 243-255. ISSN 0969-2126

Millson, S. H., Truman, A. W., King, V., Prodromou, C., Pearl, L. H., Piper, P. W. (2005) A two-hybrid screen of the yeast Proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). EUKARYOTIC CELL, 4 (5). pp. 849-860. ISSN 1535-9778

Garnett, M. J., Rana, S., Paterson, H., Barford, D., Marais, R. (2005) Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. MOLECULAR CELL, 20 (6). pp. 963-969. ISSN 1097-2765

Harris R, Esposito D, Sankar A, Maman JD, Hinks JA, Pearl LH, Driscoll PC (2004) The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR). JOURNAL OF MOLECULAR BIOLOGY, 335 (2). pp. 573-582. ISSN 0022-2836

Passmore LA (2004) The anaphase-promoting complex (APC): the sum of its parts? BIOCHEMICAL SOCIETY TRANSACTIONS, 32 (Part 5). pp. 724-727. ISSN 0300-5127

Siligardi, G., Hu, B., Panaretou, B., Piper, P. W., Pearl, L. H., Prodromou, C. (2004) Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. JOURNAL OF BIOLOGICAL CHEMISTRY, 279 (50). pp. 51989-51998. ISSN 0021-9258

Kong CG, Ito K, Walsh MA, Wada M, Liu YY, Kumar S, Barford D, Nakamura Y, Song HW (2004) Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe. MOLECULAR CELL, 14 (2). pp. 233-245. ISSN 1097-2765

Dottorini T, Vaughan CK, Walsh MA, LoSurdo P, Sollazzo M (2004) Crystal structure of a human VH: Requirements for maintaining a monomeric fragment. BIOCHEMISTRY, 43 (3). pp. 622-628. ISSN 0006-2960

Parker, J. S., Roe, S. M., Barford, D. (2004) Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO JOURNAL, 23 (24). pp. 4727-4737. ISSN 0261-4189

Oliver, A. W., Ame, J. C., Roe, S. M., Good, V., de Murcia, G., Pearl, L. H. (2004) Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. NUCLEIC ACIDS RESEARCH, 32 (2). pp. 456-464. ISSN 0305-1048

George, S., Rochford, J. J., Wolfrum, C., Gray, S. L., Schinner, S., Wilson, J. C., Soos, M. A., Murgatroyd, P. R., Williams, R. M., Acerini, C. L., Dunger, D. B., Barford, D., Umpleby, A. M., Wareham, N. J., Davies, H. A., Schafer, A. J., Stoffel, M., O'Rahilly, S., Barroso, I. (2004) A family with severe insulin resistance and diabetes due to a mutation in AKT2. SCIENCE, 304 (5675). pp. 1325-1328. ISSN 0036-8075

Kumar S, Kalsi J, Bunting K, Ravirajan CT, Latchman DS, Pearl LH, Isenberg DA (2004) Fine binding characteristics of human autoantibodies - partial molecular characterization. MOLECULAR IMMUNOLOGY, 41 (5). pp. 495-510. ISSN 0161-5890

Rowlands MG, Newbatt YM, Prodromou C, Pearl LH, Workman P, Aherne W (2004) High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. ANALYTICAL BIOCHEMISTRY, 327 (2). pp. 176-183. ISSN 0003-2697

Millson, S. H., Truman, A. W., Wolfram, F., King, V., Panaretou, B., Prodromou, C., Pearl, L. H., Piper, P. W. (2004) Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach. CELL STRESS & CHAPERONES, 9 (4). pp. 359-368. ISSN 1355-8145

Wan, P. T. C., Garnett, M. J., Roe, S. M., Lee, S., Niculescu-Duvaz, D., Good, V. M., Cancer Genome Project, [Group Author], Jones, C. M., Marshall, C. J., Springer, C. J., Barford, D., Marais, R. (2004) Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. CELL, 116 (6). pp. 855-867. ISSN 0092-8674

Roe SM, Ali MMU, Meyer P, Vaughan CK, Panaretou B, Piper PW, Prodromou C, Pearl LH (2004) The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). CELL, 116 (1). pp. 87-98. ISSN 0092-8674

Meyer, P., Prodromou, C., Liao, C. Y., Hu, B., Roe, S. M., Vaughan, C. K., Vlasic, I., Panaretou, B., Piper, P. W., Pearl, L. H. (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO JOURNAL, 23 (3). pp. 511-529. ISSN 0261-4189

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. JOURNAL OF MEDICINAL CHEMISTRY, 47 (4). pp. 935-946. ISSN 0022-2623

Kumar S, Nagl S, Kalsi JK, Ravirajan CT, Athwal D, Latchman DS, Pearl LH, Isenberg DA (2003) Anti-cardiolipin/beta-2 glycoprotein activities co-exist on human anti-DNA antibody light chains. MOLECULAR IMMUNOLOGY, 40 (8). pp. 517-530. ISSN 0161-5890

Zhang XX, Roe SM, Hou YW, Bartlam M, Rao ZH, Pearl LH, Danpure CJ (2003) Crystal structure of alanine: Glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1. JOURNAL OF MOLECULAR BIOLOGY, 331 (3). pp. 643-652. ISSN 0022-2836

Bunting, K. A., Roe, S. M., Headley, A., Brown, T., Savva, R., Pearl, L. H. (2003) Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix. NUCLEIC ACIDS RESEARCH, 31 (6). pp. 1633-1639. ISSN 0305-1048

Passmore, L. A., McCormack, E. A., Au, S. W. N., Paul, A., Willison, K. R., Harper, J. W., Barford, D. (2003) Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO JOURNAL, 22 (4). pp. 786-796. ISSN 0261-4189

Hinks, J. A., Roe, M., Ho, J. C. Y., Watts, F. Z., Phelan, J., McAllister, M., Pearl, L. H. (2003) Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 59 (7). pp. 1230-1233. ISSN 0907-4449

Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XZP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. CHEMISTRY & BIOLOGY, 10 (12). pp. 1255-1266. ISSN 1074-5521

De Koning, T. J., Snell, K., Duran, M., Berger, R., Poll-The, B-T., Surtees, R. (2003) L-Serine in disease and development. BIOCHEMICAL JOURNAL, 371 (Part 3). pp. 653-661. ISSN 0264-6021

Salmeen A, Andersen JN, Myers MP, Meng TC, Hinks JA, Tonks NK, Barford D (2003) Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. NATURE, 423 (6941). pp. 769-773. ISSN 0028-0836

Piper, P. W., Millson, S. H., Mollapour, M., Panaretou, B., Siligardi, G., Pearl, L. H., Prodromou, C. (2003) Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast. EUROPEAN JOURNAL OF BIOCHEMISTRY, 270 (23). pp. 4689-4695. ISSN 0014-2956

Meyer P, Prodromou C, Hu B, Vaughan C, Roe SM, Panaretou B, Piper PW, Pearl LH (2003) Structural and functional analysis of the middle segment of Hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. MOLECULAR CELL, 11 (3). pp. 647-658. ISSN 1097-2765

Dajani, R., Fraser, E., Roe, S. M., Yeo, M., Good, V. M., Thompson, V., Dale, T. C., Pearl, L. H. (2003) Structural basis for recruitment of glycogen synthase kinase 3 beta to the axin-APC scaffold complex. EMBO JOURNAL, 22 (3). pp. 494-501. ISSN 0261-4189

Bunting, K. A., Roe, S. M., Pearl, L. H. (2003) Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp. EMBO JOURNAL, 22 (21). pp. 5883-5892. ISSN 0261-4189

Wibley JEA, Waters TR, Haushalter K, Verdine GL, Pearl LH (2003) Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. MOLECULAR CELL, 11 (6). pp. 1647-1659. ISSN 1097-2765

Gray, C. H., Good, V. M., Tonks, N. K., Barford, D. (2003) The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO JOURNAL, 22 (14). pp. 3524-3535. ISSN 0261-4189

Boskovic, J., Rivera-Calzada, A., Maman, J. D., Chacon, P., Willison, K. R., Pearl, L. H., Llorca, O. (2003) Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs. EMBO JOURNAL, 22 (21). pp. 5875-5882. ISSN 0261-4189

Piper PW, Panaretou B, Millson SH, Truman A, Mollapour M, Pearl LH, Prodromou C (2003) Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90 beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. GENE, 302 (1-2). pp. 165-170. ISSN 0378-1119

Panaretou, B., Siligardi, G., Meyer, P., Maloney, A., Sullivan, J. K., Singh, S., Millson, S. H., Clarke, P. A., Naaby-Hansen, S., Stein, R., Cramer, R., Mollapour, M., Workman, P., Piper, P. W., Pearl, L. H., Prodromou, C. (2002) Activation of the ATPase activity of Hsp90 by the stress-regulated cochaperone Aha1. MOLECULAR CELL, 10 (6). pp. 1307-1318. ISSN 1097-2765

Wilson JR, Jing C, Walker PA, Martin SR, Howell SA, Blackburn GM, Gamblin SJ, Xiao B (2002) Crystal structure and functional analysis of the histone methyltransferase SET7/9. CELL, 111 (1). pp. 105-115. ISSN 0092-8674

Yang J, Cron P, Good VM, Thompson V, Hemmings BA, Barford D (2002) Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP. NATURE STRUCTURAL BIOLOGY, 9 (12). pp. 940-944. ISSN 1072-8368

Parkinson GN, Lee MPH, Neidle S (2002) Crystal structure of parallel quadruplexes from human telomeric DNA. NATURE, 417 (6891). pp. 876-880. ISSN 0028-0836

Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH (2002) Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor. STRUCTURE, 10 (6). pp. 751-761. ISSN 0969-2126

Pappenberger G, Wilsher JA, Roe SM, Counsell DJ, Willison KR, Pearl LH (2002) Crystal structure of the CCT gamma apical domain: Implications for substrate binding to the eukaryotic cytosolic chaperonin. JOURNAL OF MOLECULAR BIOLOGY, 318 (5). pp. 1367-1379. ISSN 0022-2836

Haider S, Parkinson GN, Neidle S (2002) Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. JOURNAL OF MOLECULAR BIOLOGY, 320 (2). pp. 189-200. ISSN 0022-2836

Ryves WJ, Dajani R, Pearl L, Harwood AJ (2002) Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 290 (3). pp. 967-972. ISSN 0006-291X

Fraser, E., Young, N., Dajani, R., Franca-Koh, J., Ryves, J., Williams, R. S., Yeo, M., Webster, M. T., Richardson, C., Smalley, M. J., Pearl, L. H., Harwood, A., Dale, T. C. (2002) Identification of the Axin and Frat binding region of glycogen synthase kinase-3. JOURNAL OF BIOLOGICAL CHEMISTRY, 277 (3). pp. 2176-2185. ISSN 0021-9258

Au SW, Leng X, Harper JW, Barford D (2002) Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10Subunit. JOURNAL OF MOLECULAR BIOLOGY, 316 (4). pp. 955-968. ISSN 0022-2836

Baldwin, D. R., Gannon, P., Bright, P., Newton, D. T., Robertson, A., Venables, K., Graneek, B., Barker, R. D., Cartier, A., Malo, J. L., Wilsher, M., Pantin, C. F. A., Burge, P. S. (2002) Interpretation of occupational peak flow records: level of agreement between expert clinicians and Oasys-2. THORAX, 57 (10). pp. 860-864. ISSN 0040-6376

Hinks, J. A., Evans, M. C., De Miguel, Y., Sartori, A. A., Jiricny, J., Pearl, L. H. (2002) An iron-sulfur cluster in the Family 4 uracil-DNA glycosylases. JOURNAL OF BIOLOGICAL CHEMISTRY, 277 (19). pp. 16936-16940. ISSN 0021-9258

Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D (2002) Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation. MOLECULAR CELL, 9 (6). pp. 1227-1240. ISSN 1097-2765

Moravek, Z., Neidle, S., Schneider, B. (2002) Protein and drug interactions in the minor groove of DNA. NUCLEIC ACIDS RESEARCH, 30 (5). pp. 1182-1191. ISSN 0305-1048

Bjoras, M., Seeberg, E., Luna, L., Pearl, L. H., Barrett, T. E. (2002) Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase. JOURNAL OF MOLECULAR BIOLOGY, 317 (2). pp. 171-177. ISSN 0022-2836

Wang, X. T., Au, S. W. N., Lam, V. M. S., Engel, P. C. (2002) Recombinant human glucose-6-phosphate dehydrogenase. EUROPEAN JOURNAL OF BIOCHEMISTRY, 269 (14). pp. 3417-3424. ISSN 0014-2956

Siligardi, G., Panaretou, B., Meyer, P., Singh, S., Woolfson, D. N., Piper, P. W., Pearl, L. H., Prodromou, C. (2002) Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50(cdc97). JOURNAL OF BIOLOGICAL CHEMISTRY, 277 (23). pp. 20151-20159. ISSN 0021-9258

LH Pearl, D Barford (2002) Regulation of protein kinases in insulin, growth factor and Wnt signalling. CURRENT OPINION IN STRUCTURAL BIOLOGY, 12 (6). pp. 761-767. ISSN 0959-440X

Ladame S, Harrison RJ, Neidle S, Balasubramanian S (2002) Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates. ORGANIC LETTERS, 4 (15). pp. 2509-2512. ISSN 1523-7060

Fogg MJ, Pearl LH, Connolly BA (2002) Structural basis for uracil recognition by archaeal family B DNA polymerases. NATURE STRUCTURAL BIOLOGY, 9 (12). pp. 922-927. ISSN 1072-8368

Vaughan, C. K., Harryson, P., Buckle, A. M., Fersht, A. R. (2002) A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 58 (4). pp. 591-600. ISSN 0907-4449

Johnson LN, De Moliner E, Brown NR, Song HW, Barford D, Endicott JA, Noble MEM (2002) Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. PHARMACOLOGY & THERAPEUTICS, 93 (2-3). pp. 113-124. ISSN 0163-7258

Sun, X. W., Neidle, S., Mann, J. (2002) Synthesis of a novel dimeric bis-benzimidazole with site- selective DNA-binding properties. TETRAHEDRON LETTERS, 43 (40). pp. 7239-7241. ISSN 0040-4039

Neidle S, Parkinson G (2002) Telomere maintenance as a target for anticancer drug discovery. NATURE REVIEWS DRUG DISCOVERY, 1 (5). pp. 383-393. ISSN 1474-1776

Dajani, R., Fraser, E., Roe, S.M., Young, N., Good, V., Dale, T. C., Pearl, L. H. (2001) Crystal structure of glycogen synthase kinase 3b: structural basis for phosphate-primed substrate specificity and autoinhibition. CELL, 105 (6). pp. 721-732. ISSN 0092-8674

Ceschini, S., Keeley, A., McAlister, M. S. B., Oram, M., Phelan, J., Pearl, L. H., Tsaneva, I. R., Barrett, T. E. (2001) Crystal structure of the fission yeast mitochondrial holliday junction resolvase Ydc2. EMBO JOURNAL, 20 (23). pp. 6601-6611. ISSN 0261-4189

Yang, J., Dokurno, P., Tonks, N. K., Barford, D. (2001) Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion. EMBO JOURNAL, 20 (14). pp. 3645-3656. ISSN 0261-4189

Zhang, X. X., Roe, S. M., Pearl, L. H., Danpure, C. J. (2001) Crystallization and preliminary crystallographic analysis of human alanine: glyoxylate aminotransferase and its polymorphic variants. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 57 (12). pp. 1936-1937. ISSN 0907-4449

Kumar S, Kalsi J, Latchman DS, Pearl LH, Isenberg DA (2001) Expression of the fabs of human auto-bodies in Eschericha coli: Optimization and determination of their fine binding characteristics and cross-reactivity. JOURNAL OF MOLECULAR BIOLOGY, 308 (3). pp. 527-539. ISSN 0022-2836

Neidle S, Read MA (2001) G-quadruplexes as therapeutic targets. BIOPOLYMERS, 56 (3). pp. 195-208. ISSN 0006-3525

Li JL, Harrison RJ, Reszka AP, Brosh RM, Bohr VA, Neidle S, Hickson ID (2001) Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. BIOCHEMISTRY, 40 (50). pp. 15194-15202. ISSN 0006-2960

Tan, T. H. P., Edgerton, S. A. V., Kumari, R., McAlister, M. S. B., Roe, S. M., Nagl, S., Pearl, L. H., Selkirk, M. E., Bianco, A. E., Totty, N. F., Engwerda, C., Gray, C. A., Meyer, D. J. (2001) Macrophage migration inhibitory factor from the parasitic nematode Trichinella spiralis. BIOCHEMICAL JOURNAL, 357 (Part 2). pp. 373-383. ISSN 0264-6021

Barford D (2001) The mechanism of protein kinase regulation by protein phosphatases. BIOCHEMICAL SOCIETY TRANSACTIONS, 29 (Part 4). pp. 385-391. ISSN 0300-5127

Mann J, Baron A, Opoku-Boahen Y, Johansson E, Parkinson G, Kelland LR, Neidle S (2001) A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity. JOURNAL OF MEDICINAL CHEMISTRY, 44 (2). pp. 138-144. ISSN 0022-2623

Song, H. W., Hanlon, N., Brown, N. R., Noble, M. E. M., Johnson, L. N., Barford, D. (2001) Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with PhosphoCDK2. MOLECULAR CELL, 7 (3). pp. 615-626. ISSN 1097-2765

Keppler, M. D., Neidle, S., Fox, K. R. (2001) Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands. NUCLEIC ACIDS RESEARCH, 29 (9). pp. 1935-1942. ISSN 0305-1048

Olson WK, Bansal M, Burley SK, Dickerson RE, Gerstein M, Harvey SC, Heinemann U, Lu X-J, Neidle S, Shakked Z, Sklenar H, Suzuki M, Tung C-S, Westof E, Wolberger C, Berman HM (2001) A standard reference frame for the description of nucleic acid base-pair geometry. JOURNAL OF MOLECULAR BIOLOGY, 313 (1). pp. 229-237. ISSN 0022-2836

Read, M., Harrison, R. J., Romagnoli, B., Tanious, F. A., Gowan, S. H., Reszka, A. P., Wilson, W. D., Kelland, L. R., Neidle, S. (2001) Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98 (9). pp. 4844-4849. ISSN 0027-8424

Myers, M. P., Andersen, J. N., Cheng, A., Tremblay, M. L., Horvath, C. M., Parisien, J-P, Salmeen, A., Barford, D., Tonks, N. K. (2001) TYK2 and JAR2 are substrates of protein-tyrosine phosphatase 1B. JOURNAL OF BIOLOGICAL CHEMISTRY, 276 (51). pp. 47771-47774. ISSN 0021-9258

Book Section

Passmore LA, Barford D, Harper JW (2005) Purification and assay of the budding yeast anaphase-promoting complex. In: Ubiquitin and Protein Degradation, Part A. Review 398. Methods in Enzymology, 398 . Academic Press, pp. 195-219. ISBN 978-012182803-5

Higgs, C., Reynolds, C. A. (2001) Modelling G-protein coupled receptors (Chapter 9). In: UNSPECIFIED, (ed.) Theoretical Biochemistry - Processes and Properties of Biological Systems. Elsevier, London, UK, pp. 341-376. ISBN 978-044450292-6

Correction

Droucheau, E., Primot, A., Thomas, V., Mattei, D., Knockaert, M., Richardson, C., Sallicandro, P., Alano, P., Jafarshad, A., Barrate, B., Kunick, C., Parzy, D., Pearl, L., Doerig, C., Meijer, L. (2004) Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors (vol 1697, pg 181, 2004). [Correction]

Meyer, P., Prodromou, C., Liao, C., Hu, B., Roe, S. M., Vaughan, C. K., Vlasic, I., Panaretou, B., Piper, P. W., Pearl, L. H. (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery (vol 23, pg 511, 2004). [Correction]

Editorial

van Montfort, R. L. M., Collins, I. (2009) Fragment-Based Methods in Drug Discovery: It's the Small Things that Matter. [Editorial]

Wilson, J. R. (2007) Targeting the JMJD2A histone lysine demethylase. [Editorial]

Letter

Harris R, Maman JD, Hinks JA, Sankar A, Pearl LH, Driscoll PC (2002) Backbone 1H, 13C, and 15N resonance assignments for the C-terminal region of Ku86 (Ku86CTR). [Letter]

Salek RM, William MA, Prodromou C, Pearl LH, Ladbury JE (2002) Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone. [Letter]

Review Article

Brennan, D. F., Barford, D. (2009) Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases. TRENDS IN BIOCHEMICAL SCIENCES, 34 (3). pp. 108-114. ISSN 0968-0004

Prodromou, C. (2009) Strategies for Stalling Malignancy: Targeting Cancer's Addiction to Hsp90. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 9 (15). pp. 1352-1368. ISSN 1568-0266

van Montfort, R. L. M., Workman, P. (2009) Structure-based design of molecular cancer therapeutics. TRENDS IN BIOTECHNOLOGY, 27 (5). pp. 315-328. ISSN 0167-7799

Pinotsis, N., Abrusci, P., Djinovic-Carugo, K., Wilmanns, M. (2009) Terminal assembly of sarcomeric filaments by intermolecular P-sheet formation. TRENDS IN BIOCHEMICAL SCIENCES, 34 (1). pp. 33-39. ISSN 0968-0004

Pearl, L. H., Prodromou, C., Workman, P. (2008) The Hsp90 molecular chaperone: an open and shut case for treatment. BIOCHEMICAL JOURNAL, 410 (Part 3). pp. 439-453. ISSN 0264-6021

Pinotsis, N., Wilmanns, M. (2008) Protein assemblies with palindromic structure motifs. CMLS-Cellular and Molecular Life Sciences, 65 (19). pp. 2953-2956. ISSN 1420-682X

Savva, R., Prodromou, C., Driscoll, P. C. (2007) DNA fragmentation based combinatorial approaches to soluble protein expression Part II: Library expression, screening and scale-up. DRUG DISCOVERY TODAY, 12 (21–22). pp. 939-947. ISSN 1359-6446

Prodromou, C., Sawa, R., Driscoll, P. C. (2007) DNA fragmentation-based combinatorial approaches to soluble protein expression Part I. Generating DNA fragment libraries. DRUG DISCOVERY TODAY, 12 (21–22). pp. 931-938. ISSN 1359-6446

Gold, M. G., Barford, D., Komander, D. (2006) Lining the pockets of kinases and phosphatases. CURRENT OPINION IN STRUCTURAL BIOLOGY, 16 (6). pp. 693-701. ISSN 0959-440X

Pearl, L. H., Prodromou, C. (2006) Structure and mechanism of the Hsp90 molecular chaperone machinery. ANNUAL REVIEW OF BIOCHEMISTRY, 75 . pp. 271-294. ISSN 0066-4154

Salmeen, A., Barford, D. (2005) Functions and mechanisms of redox regulation of cysteine-based phosphatases. ANTIOXIDANTS & REDOX SIGNALING, 7 (5-6). pp. 560-577. ISSN 1523-0864

Pearl LH (2005) Hsp90 and Cdc37 - a chaperone cancer conspiracy. CURRENT OPINION IN GENETICS & DEVELOPMENT, 15 (1). pp. 55-61. ISSN 0959-437X

Llorca O, Pearl LH (2004) Electron microscopy studies on DNA recognition by DNA-PK. MICRON, 35 (8). pp. 625-633. ISSN 0968-4328

Passmore, L. A., Barford, D. (2004) Getting into position: the catalytic mechanisms of protein ubiquitylation. BIOCHEMICAL JOURNAL, 379 (3). pp. 513-525. ISSN 0264-6021

Droucheau E, Primot A, Thomas V, Mattei D, Knockaert M, Richardson C, Sallicandro P, Alano P, Jafarshad A, Baratte B, Kunick C, Parzy D, Pearl L, Doerig C, Meijer L (2004) Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1697 (1-2). pp. 181-196. ISSN 1570-9639

Barford D (2004) The role of cysteine residues as redox-sensitive regulatory switches. CURRENT OPINION IN STRUCTURAL BIOLOGY, 14 (6). pp. 679-686. ISSN 0959-440X

Cuesta J, Read MA, Neidle S (2003) The design of G-quadruplex ligands as telomerase inhibitors. MINI REVIEWS IN MEDICINAL CHEMISTRY, 3 (1). pp. 11-21. ISSN 1389-5575

Prodromou C, Pearl LH (2003) Structure and functional relationships of Hsp90. CURRENT CANCER DRUG TARGETS, 3 (5). pp. 301-323. ISSN 1568-0096

Kumar S, Kalsi JK, Ravirajan CT, Latchman DS, Pearl LH, Isenberg DA (2002) Molecular expression systems for anti-DNA antibodies - 2. LUPUS, 11 (12). pp. 833-842. ISSN 0961-2033

Barford D (2002) Protein tyrosine phosphatases: X-ray crystallographic observation of cysteinyl-phosphate reaction intermediate. METHODS IN ENZYMOLOGY, 354 . pp. 237-251. ISSN 0076-6879

Pearl, L. H., Prodromou, C. (2002) Structure, function and mechanism of the Hsp90 molecular chaperone. ADVANCES IN PROTEIN CHEMISTRY, 59 . pp. 157-186. ISSN 0065-3233

Neidle, S. (2001) DNA minor-groove recognition by small molecules. NATURAL PRODUCT REPORTS, 18 (3). pp. 291-309. ISSN 0265-0568